系统性红斑狼疮相关性肝损害研究  

The study of liver involvement patients in systemic lupus erythematosus patients

作　　者：朱材忠[1] 李倩[2] 韩坤元[1] 陈小庄[1] 王好问[1] 

机构地区：[1]海南省人民医院风湿病与老年病科,海南海口570311 [2]武警医学院卫勤系防护医学教研室,天津300162

出　　处：《武警医学院学报》2010年第7期535-537,共3页Acta Academiae Medicinae CPAPF

摘　　要：【目的】了解系统性红斑狼疮(SLE)患者肝损害的发生率,以及肝损害与病情和自身抗体的相关性。【方法】选取1999年1月-2008年12月我院收治、资料完整的SLE患者131例,检测每名患者的肝损伤相关酶、胆红素、血浆蛋白浓度、肝脏B超及抗核抗体(ANA)、抗-ds-DNA抗体、抗-Sm抗体、抗-U1-RNP抗体、抗-SSA抗体、抗-SSB抗体、IgG、补体C3等,采用直线回归相关分析肝损害与病情活动的相关性。【结果】131例SLE患者中,SLE相关性肝损害32例,发生率为22.5%。自身抗体及补体C3降低发生率在SLE相关性肝损害和无肝损害病例中的差异均无统计学意义(P>0.05),而IgG增高发生率在二者间差异有显著性(P<0.05),SLE相关性肝损害与SLE活动性之间相关无显著性(P>0.05)。【结论】SLE患者中肝损害比较常见,SLE相关性肝损害与自身抗体和SLE病情轻重无相关性。[Objective] To investigate the prevalence of liver involvement in systemic erythematosus （SLE） patients and its correlation with disease activities or autoantibodies. [ Methods ] 131 complete data of SLE patients in our hospital from January 1999 to December 2008 were included in the study. For each eligible patient, the clinical and laboratory data were collected including symptoms, hepatic enzyme, bilirubin, sera protein concentration, hepatic ultrasonic B as well as ANA, anti-ds-DNA, anti-Sm, anti-U 1-RNP, anti-SSA, anti-SSB, IgG and complement C3. The correlation between liver involvement and disease activities were analyzed by linear regression. [Results] In all 131 SLE patients, 32 cases developed liver involvement（22.5%）. There was no significant difference between liver involvement related with SLE and non-liver involvement in autoantibodies titer and the decrease of complement C3 （P〉 0.05）. But significance was found in IgG increasing （P〈 0.05）. The correlation between liver involvement and SLE disease activities was not significant（P〉 0.05）. [Conclusion] Liver involvement in SLE is common. But liver involvement in SLE dose not correlate with autoantibodies titer and disease activities.

关 键 词：系统性红斑狼疮 肝损害 自身抗体 疾病活动度 

分 类 号：R593.24[医药卫生—内科学]