丙型肝炎患者血清补体C_3、C_4水平检测与临床关系的探讨  

Detection of serum C 3 and C 4 and clinical investigation in patients with hepatitis C

作　　者：王根维[1] 陈向伟[1] 田锋[1] 

机构地区：[1]山西医科大学微生物与免疫学教研室

出　　处：《山西医科大学学报》1999年第1期14-15,共2页Journal of Shanxi Medical University

摘　　要：对３０例丙型肝炎患者血清补体Ｃ３、Ｃ４水平进行了检测。其中急性丙型肝炎患者１５例，慢性丙型肝炎１５例，结果显示：急性期患者血清Ｃ３、Ｃ４同对照组比较差异无显著意义（Ｐ＞０１），慢性期患者血清Ｃ３、Ｃ４水平明显低于对照组，（Ｐ＜０００１，Ｐ＜０００２），且亦低于急性期患者，（Ｐ＜００１，Ｐ＜００２）。结果表明：由于丙型肝炎的发病机制与机体免疫状态密切相关，肝功能受损后可加重免疫病损，使机体免疫调节功能紊乱，出现丙型肝炎一系列临床表现，选取患者血清Ｃ３、Ｃ４水平进行检测，根据其水平变化，有助于了解肝脏损害程度。The serum C 3 and C 4 of 30 patients with hepatitis C (acute and chronic cases,each n =15)were detected.Results showed there was no difference( P> 0 1)in serum C 3 and C 4 levels in acute phase,but significant difference ( P< 0 01, P <0 02)in chronic phase,compared with the control group.And the serum C 3 and C 4 levels in chronic cases were lower than in acute cases ( P< 0 01, P <0 02).These data suggest that the pathogenesis of hepatitis C is mainly related to the immune state.The disorder of immunity appeared following liver injury,inducing the disorder of immunoregulation and a series of clinical symptoms of hepatitis.Observing the changes of serum C 3 and C 4 levels is favorable for estimating the degree of liver injury,illness and prognosis of the hepatitis.

关 键 词：丙型肝炎 免疫测定 补体3 补体4 

分 类 号：R512.63[医药卫生—内科学]