二硫化碳对粘胶纤维作业工人血浆脂质过氧化系统的影响  

Effects of Carbon Disulfide on Lipoperoxide System of Viscose Rayon Workers

作　　者：毕勇毅[1] 汪春红[1] 谭晓东[1] 闫俊[1] 王福元[1] 苏拥军[1] 邬堂春[2] 陈胜[2] 

机构地区：[1]湖北医科大学卫生学教研室 [2]同济医科大学职业医学研究所

出　　处：《工业卫生与职业病》1999年第2期79-81,共3页Industrial Health and Occupational Diseases

基　　金：湖北省科委基金;比利时ABOS-13V1396资助

摘　　要：选用血浆超氧化物歧化酶（ＳＯＤ）活性和丙二醛（ＭＤＡ）浓度作为指标初步探讨了二硫化碳对化纤作业工人体内脂质过氧化系统的影响和可能的生物学意义。结果显示：接触１５ｍｇ／ｍ３浓度二硫化碳的工人血浆丙二醛浓度为（７３４±０２１）μｍｏｌ／Ｌ，明显高于对照组（５８２±０２６）μｍｏｌ／Ｌ（Ｐ＜００１）；而其超氧化物歧化酶活性则为（１１７５４±３３９０）Ｕ／ｍｌ，明显低于对照组（１３８５４±０５１）Ｕ／ｍｌ（Ｐ＜００１）。表明ＣＳ２接触可抑制血浆ＳＯＤ的活性，导致脂质过氧化增强。Effects of carbon disulfide on lipoperoxide system of viscose rayon workers and their possible biological significance by determining the activity of superoxide dismutase(SOD)and the concentration of malonaldehyde(MDA)in plasma of the subjects were investigated.The results showed that the SOD activity in plasma of the exposed workers was lower than that in the control group(P<0 01),while the MDA concentration was significantly increased(P<0 01).These findings suggested that carbon disulfide could decrease the SOD activity and increase the lipoperoxide. \ \

关 键 词：二硫化碳 脂质过氧化 职业中毒 

分 类 号：R135.14[医药卫生—劳动卫生]