兔热暴露时脑能量代谢的变化  

Metabolic Changes of Cerebral Energy of Rabbits under Heat Stress

作　　者：华旭初[1,2] 张枫桐[1,2] 邱仞之[1,2] 王军义[1,2] 谭淼[1,2] 周俊岭[1,2] 

机构地区：[1]第一军医大学高温医学研究室 [2]第一军医大学中心实验室

出　　处：《工业卫生与职业病》1999年第2期95-97,共3页Industrial Health and Occupational Diseases

基　　金：全军"九五"指令性课题

摘　　要：用高效液相色谱法（ＨＰＬＣ）测定热应激条件下脑能量物质的变化，并以ＡＴＰ、ＡＤＰ、ＡＭＰ、ＥＣ、ＡＴＰ／ＡＤＰ和ＡＴＰ／ＡＭＰ为指标，探讨不同热应激强度下能量物质的变化情况及其发生变化的可能机理。结果表明，热射病组动物的脑ＡＴＰ、ＡＤＰ含量与对照组比较，有显著性差异（Ｐ＜００１），ＡＭＰ明显升高（Ｐ＜００１），ＥＣ及ＡＴＰ／ＡＤＰ、ＡＴＰ／ＡＭＰ的比值显著下降（Ｐ＜００１）。提示，当动物发生热射病时，脑组织能量物质严重不足，能量贮存重度匮乏。Cerebral energy substances were measured by HPLC when the New Zealand rabbits were exposed to high temperature,and the mechanism of these changes was investigated with following indexes:ATP,ADP,AMP,EC,ATP/ADP and ATP/AMP under various heat stresses.The results showed that ATP,ADP,EC,ATP/ADP and ATP/AMP of the brain in heat stroke group were significantly reduced(P<0 01),while AMP was significantly increased as compared with that of the control group.It indicated insufficient energy substances and inadequate energy storage in brain when heat stroke.

关 键 词：热应激 能量代谢 热射病 脑代谢 

分 类 号：R594.11[医药卫生—内科学]