乳酸环丙沙星眼用即型凝胶的研制  

Preparation of ciprofloxacin lactate in situ forming eye gel

作　　者：张建强[1] 杨放[1] 姚洁[1] 李蔷薇[1] 何正有[1] 邓小宽[1] 陈书峰[1] 金英华[1] 刘君焱[1] 胡杨洋[2] 

机构地区：[1]中国医药集团总公司四川抗菌素工业研究所,成都610052 [2]成都中医药大学,成都611137

出　　处：《中国抗生素杂志》2010年第4期292-295,313,共5页Chinese Journal of Antibiotics

摘　　要：目的研制乳酸环丙沙星眼用即型凝胶。方法以泊洛沙姆407为温敏型材料制备乳酸环丙沙星眼用即型凝胶,通过对胶凝温度的考察确定处方,考察了乳酸环丙沙星眼用即型凝胶的黏度,采用无膜溶出模型对药物的体外释放机制进行研究,对制剂的眼刺激性进行评价。结果确定18%的泊洛沙姆407作为乳酸环丙沙星眼用即型凝胶的基质。药物的体外释放呈零级动力学特征,释放量取决于凝胶溶蚀量。该制剂对兔眼无刺激。结论该制剂制备方法简单,剂量易于控制,展现出良好的眼部应用前景。Objective To study ciprofloxacin lactate（CPFL） in situ forming eye gel. Methods Poloxamer 407 was used as themosensitive material for the CPFL eye gel. The formulation was selected according to the temperature of gel. The viscosity of ciprofloxacin lactate in situ forming eye gel were investigated. A novel membraneless model was used to study on drug release in vitro. Eye irritation experiments were performed with rabbit. Results 18% poloxmar 407 were suitable to CPFL in situ forming eye gel. Drug release followed zero-order kinetics, and the quantity of drug release was controlled by gel erosion. The preparation were nonirritant. Conclusion The preparation is simple in method and easy to control in dosage, therefore it showed great potential in ophthalmic application.

关 键 词：乳酸环丙沙星 眼用即型凝胶 泊洛沙姆407 

分 类 号：R978.19[医药卫生—药品]