白细胞介素4及受体基因多态性与维吾尔族变应性鼻炎相关性的研究  

Study on Relationship between Interleukin-4 Receptor Gene Polymorphism and Allergic Rhinitis in Uyghurs

作　　者：沙吾拉西[1] 戴江红[1] 姜孝芳[2] 迪丽达尔.伊地热斯 高丽[2] 

机构地区：[1]新疆医科大学公共卫生学院,新疆乌鲁木齐830011 [2]新疆医科大学基础医学院,新疆乌鲁木齐830011

出　　处：《环境与健康杂志》2010年第5期407-410,共4页Journal of Environment and Health

基　　金：新疆自治区自然科学基金资助项目(200821136);新疆自治区高校科研计划重点项目(XJEDU2006I41)

摘　　要：目的探讨白细胞介素4(IL-4)及受体(IL-4R)基因多态性与维吾尔族人群(维族)变应性鼻炎的关联。方法采用人群为基础的病例对照研究成组设计,选择新疆喀什地区维族变应性鼻炎(AR)患者109例为病例组,以同居住地、同民族、同性别作为匹配条件,选取393例非AR居民为对照组。采用聚合酶链反应-限制性片段长度多态性法(PCR-RFLP)检测IL-4rs2243283C/G和IL-4R rs6498011A/G位点基因多态性,比较其在病例组与对照组间基因型和等位基因的频率分布。结果 IL-4R基因rs6498011A/G位点在病例组和对照组间基因型和等位基因型分布频率差异有统计学意义(P=0.008)。IL-4基因rs2243283C/G位点在两组间分布差异无统计学意义(P=0.999)。结论 IL-4Rrs6498011A/G位点与维族变应性鼻炎密切相关。Objective To know the relationship between the gene polymorphism of interleukin-4receptor （IL-4R） and the allergic rhinitis in Uygur. Methods Community-based case-control study was performed among 109 Uyghur patients with allergic rhinitis living in Kashi area in Xinjiang. The IL-4R rs6498011A/G and IL-4 rs2243283 C/G polymorphism were genotyped by polyrnerase chain reaction-restriction fragment length polymorphism （PCR-RFLP）, the distribution frequency of genotype and allele between the two groups was analyzed. Results The distribution frequency of genotypes and alleles of IL-4R rs6498011A/G revealed significant difference between ease group and control group （P〈0.001, P=0.008）. The distribution frequency of genotypes and alleles of IL-4 rs2243283C/G revealed no significant difference between the two groups （P=0.999）. Conclusion The results of the present paper suggest that the IL-4R rs6498011MG is strongly associated with allergic rhinitis in Uyghur.

关 键 词：变应性鼻炎 受体 白介素4 多态性 基因型 

分 类 号：R181.3[医药卫生—流行病学]