氧化应激在阿尔茨海默病中的作用及相关药物研究进展  

Role of oxidative stress on Alzheimer's disease and research advance of new drugs

作　　者：储奔虹[1] 董文心[1] 

机构地区：[1]上海医药工业研究院,上海200437

出　　处：《中国新药杂志》2010年第11期940-943,948,共5页Chinese Journal of New Drugs

摘　　要：阿尔茨海默病(Alzheimer s disease,AD)是以进行性认知功能障碍和记忆力损害为主的中枢神经系统的退行性疾病,其发病机制十分复杂。氧化应激可损伤细胞内多种生物大分子。在AD患者脑中,脂质、蛋白质、DNA、RNA和糖类都存在过氧化形式。氧化应激也参与了形成老年斑、神经原纤维缠结以及神经元细胞凋亡。此外,氧化应激还与AD发病机制的神经炎症和线粒体功能异常有关联,与其共同加剧了AD的发生。具有强抗氧化活性的生物活性分子(如褪黑素和吡咯喹啉醌)有望成为很有前途的以氧化应激为靶点的抗AD治疗药物。Alzheimer＇s disease（AD） is one of the degenerative diseases in central nervous system characterized by the progressive cognitive disorder and memory impairment and memory loss.The pathogenesy of AD is complicated.Oxidative stress can injure many kinds of biomacromolecule.Lipid,protein,DNA,RNA and carbohydrate had been found to remain their peroxidative forms in AD brains.Oxidative stress also plays an important part in the formation of senile plaques,neurofibrillary tangles and apoptosis of neurons.In addition,oxidative stress also has some relationships with inflammation and mitochondria malfunction which aggravate the process of AD together with oxidative stress.Bioactive molecules with strong anti-oxidative activities such as melatonin and pyrroloquinoline quinone,become promising anti-AD drugs targeted at oxidative stress.

关 键 词：阿尔茨海默病 氧化应激 Β-淀粉样肽 TAU蛋白 抗氧化药 

分 类 号：R971[医药卫生—药品]