猪胸腺素对小鼠及中老年人免疫功能的调节作用  

MODULATING EFFECT OF SWINE THYMOSIN ON THE IMMUNOFUNCTION OF MIDDLEAGED AND AGED AND MICE

作　　者：张鸿逵[1] 王学曾 邱桂兰[1] 韩玉美[2] 刘传笃[2] 刘昌俊[1] 崔正言 张天民 

机构地区：[1]山东省千佛山医院 [2]山东省医学科学院

出　　处：《山东医科大学学报》1990年第3期69-73,共5页Acta Academiae Medicinae Shandong

摘　　要：将BALB/c小鼠分为猪胸腺素(ST)组、猪胸腺素+维生素E(ST+VE)组、维生素E(VE)组和生理盐水(NS)组,研究发现ST、ST+VE两组脾细胞LCLPFC与血浆cGMP,胸腺重量及生存期均显著高于NS组,肿瘤发生率低于NS组。临床观察117例中老年人,ST组的Et,Ea,LCT,OT值与一般生理机能均显著提高,CIC,AA与感染性疾病减少,VE组除Et,LCT提高和CIC,AA减少外,余无明显改变。停ST12个月时,LCT值下降明显,消化系感染疾病增多,提示停药1年时应适当补充ST。The result of animal experiment with BALB/c mice(10 months age)showed that the spleen LCT and PFC,plasma cGMP,thymus weight and survival time of the groups treated with swine thymosin(ST)only and ST combined with VE were significantly higher and the rate of tumor incidence were lower than that of saline control group,and there was no difference between YE group and saline control group.Clinical study showed that the Et,Ea,LCT OT value and general physical function of fifty nine middleaged and aged people treated with ST increased significantly,and the CIC,AA and the rate of infectious incidence decreased considerablly,but the parame- ters of the group treated with VE had no valuable change except the increase of LCT and CIC and the decrease of AA,When the use of ST had been stopped for 12 months,the value of LCT decreased considerablly and the rate of the infectious incidence of alimentary system increased.The phenomenon suggests that appropriate amount ST should be supplied again after the use of ST stopped for 1 year.

关 键 词：胸腺素 免疫活性 猪 老年人 小鼠 

分 类 号：R979.5[医药卫生—药品]