吸烟对人末梢血淋巴细胞微核和核形态的影响  

EFFECTS OF SMOKING ON MICRONUCLEUS AND NUCLEAR FORMATION IN HUMAN LYMPHOCYTES

作　　者：徐厚铨[1] 梁永慧 丁恬[1] 杨志祥[1] 粘翠彬 

机构地区：[1]山东医科大学环境卫生学教研室 [2]济南市教育学院

出　　处：《山东医科大学学报》1990年第3期57-59,73,共3页Acta Academiae Medicinae Shandong

摘　　要：用人体末梢血微核测试法对吸烟支数不同的178名男性教师进行生物材料监测,观察人体末梢血淋巴细胞微核和核变形。结果表明不吸、偶吸和现吸3组间在3项微核指标与5项核变形指标上有显著性或非常显著性差异、吸烟量与淋巴细胞微核3项指标之间存在明显的剂量-反应关系。The genotoxic effect of smoking was studied employing micro- nucleus test by human skin puncture and examining micronuclei and nu- clear formation in human lymphocytes among 178 male teachers aged 20 years and over.Frequency of micronucleus(MNF),frequency of cell micro- nuclei(CMF),rate of micronucleus men(MMR)and frequency of irreg- ular nucleus(INF)was detected among current-smokers and accidental- smokers and nonsmokers.The result was established that significance and highly significance difference observed by statistical treatment.Relation of dose-response was established between smoking amount and micronuclei number.Indices of micronuclei and nuclear anomaly might be useful in studying smoking induced mutagenesis.

关 键 词：吸烟 淋巴细胞 核变形 微核 

分 类 号：R163[医药卫生—公共卫生与预防医学]