抗T淋巴细胞单克隆抗体治疗苯中毒致再生障碍性贫血  

THE TREATMENT OF APLASTIC ANEMIA DUE TO BENZOLISM WITH MONOCLONAL ANTI HUMAN T LYMPHOCYTE ANTIBODY

作　　者：王鲁群[1,2] 迟翠芳[1,2] 张明珙[1,2] 宋素芹[1,2] 孔凡盛[1,2] 黄宁 刘希民[1,2] 李嵋 张东红[1,2] 周兰月 

机构地区：[1]济南军区总医院血液病科 [2]山东医科大学附属医院血液病研究室

出　　处：《山东医科大学学报》1999年第1期68-69,73,共3页Acta Academiae Medicinae Shandong

摘　　要：为探讨免疫调节疗法对苯中毒所致再生障碍性贫血（ＡＡ）的疗效，采用抗人Ｔ淋巴细胞单克隆抗体（ＭｃＡｂＴ）ＳＭＵ３（抗ＣＤ３）和ＳＭＵ８（抗ＣＤ８）治疗８例苯中毒所致ＡＡ，基本治愈４例，缓解１例，明显进步３例。治疗前ＣＤ＋４／ＣＤ＋８比例倒置，淋巴细胞表面ＨＬＡＤＲ抗原表达增高；治疗后ＣＤ＋４／ＣＤ＋８比例及ＨＬＡＤＲ抗原表达恢复正常。无血清病及血细胞减少等严重毒副作用。证明苯中毒所致ＡＡ存在细胞免疫功能紊乱。To study the curative effect of immunomodulator on aplastic anemia due to benzolism, monoclonal anti human T lymphocyte antibody SMU3 (anti CD3) and SMU8 (anti CD8) were used in 8 patients. 4 cases were cured, 1 was remitted and 3 achieved good progress. Before SMU3 and SMU8 therapy, there was the reverse of T cell subsets CD4/CD8 ratio and higher expression of the HLA DR antigen on the lymphocytes surface, which were normalized after SMU3 and SMU8 therapy. No serious toxic and side effects, such as serum disease and hematocytopenia manifested. The study demonstrated that patients with aplastic anemia due to benzolism have disturbance of cellular immune function and respond well to treatment of monoclonal anti human T lymphocyte antibody.

关 键 词：再生障碍性贫血 苯中毒 McAb-T 治疗 贫血 

分 类 号：R556.505[医药卫生—血液循环系统疾病]