蜈蚣提取物对S180及H22荷瘤小鼠的影响及其毒性的实验研究  

Effects of Centipede Extracts on Normal Mouse and S180,H22 Bearing Mouse

作　　者：徐晓琳[1] 王春梅[1] 赓迪[1] 张丽[1] 张露[1] 胡斌[1] 

机构地区：[1]北京中医药大学中药学院,北京100102

出　　处：《中药材》2010年第4期499-503,共5页Journal of Chinese Medicinal Materials

基　　金：留学回国人员科研启动项目

摘　　要：目的:研究蜈蚣提取物对正常小鼠和移植性S180、H22荷瘤小鼠的影响及其毒性。方法:分别对正常小鼠和S180、H22荷瘤小鼠经口服给药12 d,观察小鼠的生长情况、肿瘤生长情况、体重及小鼠胸腺、脾脏指数变化,毒性实验分别采用最大给药量口服一次给药和多次给药方法观察。结果:蜈蚣水提物对正常小鼠影响较小,蜈蚣醇提物对小鼠肝指数有增大作用。蜈蚣醇提物中低剂量组对S180荷瘤鼠肿瘤增殖有一定的抑制趋势,但无统计学差异,高剂量组无抑制作用。蜈蚣水提物对H22荷瘤小鼠不具有抑制肿瘤生长的作用,且能导致荷瘤小鼠衰弱和死亡。急性毒性实验中,小鼠给药48 g/kg,未见致死毒性。结论:蜈蚣水提物不能抑制荷瘤小鼠肿瘤增殖,蜈蚣醇提物有一定毒性,提示蜈蚣单独用于治疗癌症尚需深入研究。Objective：To study the effects of centipede extracts on H22 tumor-bearing mouse,sarcoma S180 mouse and normal mouse.Methods： Normal and tumor-bearing mouse were orally administrated by centipede extracts.Rate of restraining tumor,index of thymus and spleen were calculated after 12 days treatment.Acute toxicity testing tried to figure out In LD50 of centipede extracts.Results： The restraining tumor rates of centipede ethanol extracts at low and medium doses were 22.2% and 17.88%.There was no tumor restraining effect by the high dose treatment.The tumor growth of the H22 model mouse was not restrained by the centipede water extracts.There were no significant differences among the treatments in their spleen weight and spleen index.In LD50 test,the administrating dosages of centipede extracts given to the mouse were 48 times those given to patients on clinic.The result showed no mouse dead in centipede group.Conclusion： Centipede water extracts had no anti-tumor effect on tumor-bearing mouse.There is certain toxicity in ethanol extracts of centipede,suggesting that centipede alone for treatment of cancer needs further study.

关 键 词：蜈蚣提取物 H22小鼠 S180小鼠 毒性 抗肿瘤作用 

分 类 号：R285.5[医药卫生—中药学]