补肾活血法治疗慢性肾盂肾炎的临床研究  

Clinical Study on Treating Chronic Pyelonephritis with Kidney-Nourishing and Blood-Activating Therapy

作　　者：曹和欣[1,2] 何立群[1,2,3] 侯卫国[1,2] 蒋宇峰[1,2] 

机构地区：[1]上海中医药大学附属曙光医院肾内科,上海200021 [2]上海中医药大学肝肾疾病病证教育部重点实验室,上海201203 [3]上海市高校中医内科E-研究院,上海201203

出　　处：《上海中医药大学学报》2010年第3期37-39,共3页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：上海市教育委员会E-研究院建设计划资助项目(E03008);上海市教委高校创新团队资助项目

摘　　要：目的:观察补肾活血法治疗慢性肾盂肾炎的临床疗效。方法:将72例慢性肾盂肾炎患者随机分为治疗组和对照组,每组各36例。治疗组给予口服补肾活血方,对照组给予左氧氟沙星治疗,两组疗程均为12周。观察两组患者治疗前后临床症状、体征的改变以及尿N-乙酰-β-D-氨基葡萄糖苷酶(NAG)、视黄醇结合蛋白(RBP)和β_2微球蛋白(β_2-MG)的变化情况。对临床痊愈者随访6个月,观察复发率情况。结果:治疗组临床总有效率为86.11%,对照组为63.89%,差异有统计学意义(P<0.01);治疗组尿RBP、β_2-MG和NAG下降明显,其中RBP、β_2-MG明显低于对照组,差异有统计学意义(P<0.01);治疗组复发率显著低于对照组(P<0.01)。结论:补肾活血法治疗慢性肾盂肾炎,可显著改善患者临床症状和肾小管功能,降低复发率,从而提高治愈率。Objective ： To observe the therapeutic efficacy of kidney-nourishing and blood-activating therapy for chronic pyelo- nephritis. Methods ： A total of 72 patients with chronic pyelonephritis were randomly divided into treatment group and control group, with 36 eases in each. The treatment group was treated with kidney-nourishing and blood-activating decoction, and the control group was treated with levofloxacin, both of them were treated for 12 weeks. The clinical Symptoms and signs, urinary N-acetyl-β-D- glucosaminidase（ NAG）, retinol-binding protein （RBP）, β2 microglobulin（β2-MG） of the two groups were detected before and after treatment. A six-month follow up study of the healed cases in both groups were also carried out to investigate the relapse rate. Results ： The total effective rate was 86.11% in treatment group and 63.89% in control group （ P 〈 0.01 ）. After treatment the urinary RBP, β2-MG and NAG of treatment group decreased significantly, and there were significant differences in RBP and β2-MG between treatment group and control group（ P 〈 0.01 ）. The relapse rate of treatment group was significantly lower than that of control group （P 〈 0.01 ）. Conclusion： Treating chronic pyelonephritis with kidney-nourishing and blood-activating therapy can significantly improve the clinical symptoms and renal function, reduce recurrence and thus increase the cure rate.

关 键 词：慢性肾盂肾炎 补肾活血法 临床研究 中医药疗法 

分 类 号：R277.5[医药卫生—中医学]