链霉菌次生代谢中双因子调控系统的研究进展  

Biosynthetic Regulation of Secondary Metabolites in Streptomycetes by Two-component Regulatory Systems

作　　者：宫彩霞[1,2] 李爱英[1,2] 

机构地区：[1]华中师范大学生命科学学院,湖北武汉430079 [2]华中师范大学农药与化学生物学教育部重点实验室,湖北武汉430079

出　　处：《微生物学通报》2010年第6期904-911,共8页Microbiology China

基　　金：国家自然科学基金项目(No30770036);教育部高等学校博士学科点专项科研基金项目(No20070511004);教育部留学回国人员科研启动基金资助项目

摘　　要：链霉菌次生代谢产物的生物合成受到严格和复杂的调控,而双因子调控系统是其中重要的一类调控因子,在链霉菌中广泛存在,且存在作用方式的多样性和作用机制的复杂性。就近些年研究较多的参与链霉菌次生代谢的两类双因子调控系统(真核型和原核型)的研究状况做了综述,重点阐明其作用机制,并对其研究趋势以及在药物代谢工程中的应用前景进行了展望。A vast number of secondary metabolites are produced in Streptomycetes under the tight control by many regulators,including two-component regulatory systems.Two-component regulatory systems with high diversity are widely distributed in Streptomycetes and perform positive or negative regulation by different and complex modes during secondary metabolites biosynthesis.Here,we reviewed some research advances on these systems involved in secondary metabolites accumulation in streptomycetes,mainly focusing on the clarification of their action modes.We also prospected the research trends in this field and application of two-component regulatory systems in the metabolic engineering of natural products.

关 键 词：链霉菌 次生代谢 合成调控 双因子调控系统 

分 类 号：Q935[生物学—微生物学]