静脉注射胺碘酮治疗术后心衰伴室性心律失常的疗效观察  

Clinical Efficacy of Intravenous Administration of Amiodarone in the Treatment of Postoperative Heart Failure Combined with Ventricular Tachycardia

作　　者：李晓丽[1] 罗羽慧[1] 吴文利[1] 

机构地区：[1]重庆市中山医院心内科,重庆市400013

出　　处：《中国药房》2010年第24期2235-2236,共2页China Pharmacy

摘　　要：目的:观察静脉注射胺碘酮对术后心衰伴室性心律失常患者的疗效。方法:选择术后心衰并有室性心动过速、多源性室性早搏的患者42例,经利多卡因治疗无效,胺碘酮150mg稀释后静脉滴注约30min后,再给以胺碘酮0.5～1mg·min-1维持,24h总量为1000～1200mg。每小时记录用药前后心律、心率、血压及心衰症状等,观察24h。结果:治疗后患者显效17例(40%)、有效20例(47%)、无效5例(12%),治疗前、后差异有统计学意义(P<0.05)。用药后心功能改善情况,差异有统计学意义(P<0.05)。结论:静脉注射胺碘酮治疗术后心衰伴室性心律失常有效,对心功能改善有益。OBJECTIVE：To observe the effect of intravenous administration of amiodarone on postoperative heart failure and ventricular arrhythmia.METHODS：A total of 42 postoperative heart failure patients with ventricular tachycardia and multi-source ventricular premature beat were treated with lidocaine,but clinical efficacy was not obtained.Those patients received intravenous administration of diluted amiodarome 150 mg.After 30 minutes the dose of amiodarone was kept at 0.5～1.0 mg·min-1,and the total dosage ranged from 1 000 mg to 1 200 mg within 24 h.Clinical symptoms were recorded in every hour,such as cardiac rhythm,heart rate,blood pressure,heart failure.RESULTS：After 24 h of treatment,17 cases of ventricular arrhythmia had apparent effect（40%）,20 cases of partial effect（47%）,5 cases of no effect（12%）,there were statistical significance in difference before and after treatment（P0.05）.The improvement of heart function was significantly different before and after treatment（P0.05）.CONCLUSION：Intravenous administration of amiodarone has effect on postoperative heart failure and ventricular arrhythmia,and is beneficial to the improvement of cardiac function.

关 键 词：胺碘酮 室速 室早 心衰 治疗 

分 类 号：R917[医药卫生—药物分析学]