氨氯地平治疗原发性高血压的疗效观察  

Clinical Efficacy Analysis of Amlodipine in the Treatment of Primary Hypertension

作　　者：吴凯[1] 朱立勤[1,2,3] 孙鹤[2] 肖怡然[3] 李敬永[3] 

机构地区：[1]天津市第一中心医院,天津市300192 [2]天津大学药物科学与技术学院,天津市300072 [3]天津医科大学,天津市300070

出　　处：《中国药房》2010年第24期2244-2246,共3页China Pharmacy

摘　　要：目的:观察氨氯地平治疗原发性高血压的疗效和安全性。方法:选择原发性高血压患者76例,随机分为对照组35例和治疗组41例。对照组使用卡托普利12.5mg,qd;治疗组使用氨氯地平5mg,qd。记录用药治疗期间血压的变化情况,以用药前和用药后第10天血压指标判断疗效。结果:治疗组治疗前、后收缩压值和舒张压值均明显降低,差异有统计学意义(P<0.01);治疗组降低收缩压的作用弱于对照组,2组对舒张压的降低作用没有明显差异;对照组显效率为28.57%,总有效率为57.14%,治疗组显效率为75.61%,总有效率为87.80%;治疗组与对照组的显效率和总有效率比较均有显著性差异(P<0.01)。结论:氨氯地平治疗原发性高血压疗效显著,优于卡托普利。OBJECTIVE：To analyze clinical efficacy and safety of amlodipine in the treatment of primary hypertension.METHODS：76 patients with primary hypertension were randomly divided into control group（n=35） and treatment group（n=41）.Control group were treated with captopril 12.5 mg once a day and treatment group were given amlodipine 5 mg once a day.The change of blood pressure was recorded during treatment.Blood pressure index at 10th day before and after treatment were used to evaluate clinical efficacy.RESULTS：After treatment systolic blood pressure and diastolic blood pressure were significantly decreased,there was significant difference before and after treatment（P0.01）;the decrease of systolic blood pressure in treatment group was smaller than in control group while there had no significant difference.In control group effective rate was 28.57% and total response rate was 57.14%.In treatment group effective rate was 75.61% and total response rate was 87.80%.There were significant difference in effective rate and total response rate between two groups（P0.01）.CONCLUSION：Amlodipine is superior to captopril in the treatment of primary hypertension.

关 键 词：氨氯地平 卡托普利 原发性高血压 疗效分析 

分 类 号：R972.4[医药卫生—药品]