奥美拉唑和雷尼替丁治疗消化性溃疡的系统评价  

Systematic Review on Omeprazole and Ranitidine in the Treatment of Peptic Ulcer

作　　者：史宏妍[1] 刘伟[2] 

机构地区：[1]河南省中医院,郑州市450003 [2]郑州大学药学院,郑州市450003

出　　处：《中国药房》2010年第24期2287-2289,共3页China Pharmacy

摘　　要：目的:评价奥美拉唑和雷尼替丁在治疗消化性溃疡方面的疗效和不良反应。方法:电子检索中文科技期刊数据库、万方数据库。采用Revan5.0软件进行Meta分析,对可合并分析资料无异质性者使用固定效应模型,有异质性者分析异质性产生原因,并使用敏感性分析或亚组分析处理,若仍无法消除异质性,采用随机效应模型合并分析。结果:奥美拉唑与雷尼替丁治疗消化性溃疡的总有效率,差异有统计学意义[P<0.05,OR=3.96,95%C(I2.57,6.11)];奥美拉唑的不良反应远低于雷尼替丁。结论:Meta结果显示,奥美拉唑治疗消化性溃疡明显优于雷尼替丁。OBJECTIVE：To evaluate clinical efficacy and ADR of omeprazole and ranitidine in the treatment of peptic ulcer.METHODS：Literatures were retrieved from China scientific journal database and Wanfang database.Meta-analysis was conducted using Revan 5.0 software.Fixed effect model was used to combined information and non-heterogeneity.The cause of heterogeneity was also analyzed.Sensitivity analysis and subgroup analysis were used to dispose the heterogeneity.Random effect model was used for analysis if the heterogeneity cannot be eliminated.RESULTS：Total effective rate of omeprazole for peptic ulcer was significantly different from ranitidine [P0.05,OR=3.96,95%CI（2.57,6.11）].The incidence of omeprazole-induced ADR was lower than that of ranitidine-induced ADR.CONCLUSION：Results of RCT and meta-analysis manifest clinical efficacy of omeprazole is significantly better than ranitidine in the treatment of peptic ulcer.

关 键 词：奥美拉唑 雷尼替丁 系统评价 循证医学 

分 类 号：R917[医药卫生—药物分析学]