美罗培南致过敏性皮炎1例并文献分析  

Literature Analysis of 1 Case of Allergic Dermatitis Induced by Meropenem

作　　者：黄静[1] 李宝忠 严可 

机构地区：[1]重庆市第三人民医院呼吸内科,重庆市400014 [2]重庆石柱县中医院内科,重庆市400109

出　　处：《中国药房》2010年第24期2289-2290,共2页China Pharmacy

摘　　要：目的:分析美罗培南所致药品不良反应的一般规律和临床特点,为临床合理用药提供参考。方法:报道1例80岁男性患者使用美罗培南后皮肤出现水疱、大疱样改变,并检索1994年1月～2009年12月国内医药期刊报道的美罗培南致不良反应病例,并进行分析。结果:美罗培南不良反应少,常见为腹泻、皮疹、肝功异常等。结论:尽管美罗培南不良反应少,致过敏性皮炎亦较少见,但仍应引起临床重视。OBJECTIVE：To study the general regularity and characteristics of adverse drug reaction caused by meropenem,and to provide reference for rational use of drugs.METHODS：Vesicle and bullous change occurring in one patient with allergic dermatitis,age of 80,treated with meropenem were analyzed.Literatures about meropenem-induced ADR reported in domestic pharmaceutical journals from Jan.1994 to Dec.2009 were collected and analyzed statistically.RESULTS：Meropenem rarely caused ADR.The most clinical manifestations were diarrhea,rash and abnormality of liver function.CONCLUSION：Meropenem-induced ADR case is rare as well as allergic dermatitis.Great importance should be attached to meropenem-induced ADR.

关 键 词：美罗培南 不良反应 过敏性皮炎 

分 类 号：R969.3[医药卫生—药理学]