胆汁对小鼠细粒棘球蚴囊肿生长的影响  

Effect of Bile Against Echinococcus granulosus in Mice

作　　者：马志刚[1] 张示杰[2] 孙红[2] 张宏伟[2] 彭心宇[2] 

机构地区：[1]石河子大学医学院 [2]石河子大学医学院第一附属医院肝胆外科,新疆石河子832008

出　　处：《农垦医学》2010年第1期14-16,共3页Journal of Nongken Medicine

基　　金：国家科技支撑计划资助项目(No.2009BAI82B06)

摘　　要：目的:探讨胆汁对细粒棘球蚴囊肿生长的影响。方法:实验组腹腔接种经胆汁处理20分钟后的原头蚴,对照组接种生理盐水处理的原头蚴,3月后按囊湿重、常规病理切片进行评价。结果:实验组和对照组囊湿重分别为11.94±6.56mg,23.06±3.02mg,差异有显著性(P<0.01);囊肿病理损害程度无差异(P>0.05)。结论:胆汁短时间内不能直接杀灭包虫原头蚴,但是可以抑制包虫的囊肿生长。Objective： To discuss the effect of bile against echinococcus granulosus.Methods：Forty Female Kunming mices were randomly divided into experimental groups and control groups,mice were infected by intraperitoneal injection E.g cyst fluid from sheep,Mice in experimental groups were administered by the prostoscoleces were treated with bile for 20 minute,and the control with normal saline.3 months after infection,all the mice were sacrificed to evaluate the efficacy,which covered cyst wet weight,pathological change.Results：Cyst wet weight of experimental group and control group were 23.06±3.02mg,11.94±6.56mg（P〈0.01）,there was no significant difference in the histopathological changes of two groups（P〉0.05）.Conclusion：The bile did＇nt kill directly Echinococcus granulosus,but echinococcus cyst was to inhibit the growth.

关 键 词：细粒棘球蚴 包虫囊肿 胆汁 

分 类 号：R532.32[医药卫生—内科学]