A771726在大鼠体内肝肠循环的研究  

Enterohepatic cycling of A771726 in rats

作　　者：程娟[1] 李俊[1] 宋珏[1] 郑世瑞[1] 李浩[1] 孔一帆[1] 

机构地区：[1]安徽医科大学药学院,合肥230032

出　　处：《安徽医科大学学报》2010年第3期338-341,共4页Acta Universitatis Medicinalis Anhui

基　　金：安徽省教育厅自然科学研究项目(编号:2004kj196)

摘　　要：目的研究A771726在大鼠体内肝肠循环情况。方法运用配对大鼠肝肠循环模型研究A771726在大鼠体内从胆汁重吸收的药动学过程,采用HPLC法测定血浆中A771726浓度,药动学参数用DAS软件统计矩法计算。结果配对大鼠肝肠循环模型表明,胆汁供体大鼠和胆汁受体大鼠的AUC分别为(1352.85±184.51)mg/(L.h)、(314.94±21.15)mg/(L.h)。结论 A771726静脉注射后存在肝肠循环现象,约有静脉注射给药量的23.8%进入肝肠循环。Objective To investigate the process of enterohepatic cycling of A771726 in rats. Methods Rat enterohepatic cycling model was applied to study the process of biliary reabsorption of A771726. Plasma A771726 levels were detected by a HPLC method. The pharmacokinetic parameters were estimated with the soft ware DAS using non-compartmental analysis. Results In the enterohepatic cycling model,the AUC values of bile-recipient rats and bile-donor rats were estimated to be （1352.849 ± 184.51） mg/（L·h） and（314.94±21.15） mg/（L·h）,respectively.Conclusion The findings suggestes that enterohepatic cycling of A771726 exist in rats after iv administration. Approximately 23.8% of the intravenous administration dosage enters the enterohepatic circulation.

关 键 词：色谱法 高压液相 异恶唑类/药物代谢动力学 异恶唑类/投药和剂量 

分 类 号：R969.1[医药卫生—药理学] R331.37[医药卫生—药学]