CA125在正常子宫内膜及其病变组织中的表达及意义  

CA125 expression and its significance in normal and pathological endometrial tissues

作　　者：何淑明[1] 邢福祺[1] 隋洪[2] 吴又明[2] 王永莉[2] 黄东[2] 陈光辉[2] 孔紫靖[2] 

机构地区：[1]南方医科大学南方医院妇产科,广州510515 [2]南方医科大学附属小榄医院妇产科,广东中山528415

出　　处：《解放军医学杂志》2010年第6期702-705,共4页Medical Journal of Chinese People's Liberation Army

基　　金：广东省医学科学技术研究基金(A2007745);广东省科技计划项目(2007B031515002);中山市科技计划项目(20071A070)

摘　　要：目的探讨肿瘤相关抗原CA125在正常子宫内膜及其病变组织中的表达和意义。方法收集2005年1月-2009年12月经分段诊刮或宫腔镜检查获得的子宫内膜标本242例,其中正常增殖期内膜24例,分泌期内膜21例,非功能性子宫内膜息肉24例,单纯型增生过长24例,复杂型增生过长26例,子宫内膜腺癌123例。采用免疫组织化学EliVision法检测CA125在子宫内膜及其病变组织中的表达情况。结果 CA125在子宫内膜及其不同病变组织中的表达程度不同:分泌期及正常增殖期子宫内膜组织为弱阳性及中等程度阳性,二者比较差异无统计学意义(P>0.05);非功能性息肉、复杂型增生过长组织中等以上阳性率高于单纯性增生过长,三者CA125阳性特点差异有统计学意义(χ2=9.652,P<0.05);子宫内膜癌CA125阳性表达在病理Ⅰ、Ⅱ级组织之间差异无统计学意义(χ2=3.698,P>0.05),但在Ⅰ、Ⅱ级组织中的阳性表达显著高于Ⅲ级组织(χ2=11.975,P<0.01)。结论 CA125在子宫内膜及其病变组织中的表达与内膜组织的病理演变进程一致。Objective To investigate the expression of tumor-associated antigen CA125 and its significance in normal and pathological endometrial tissues. Methods A total of 242 patients were divided into six groups,including proliferative phase endometrium group （n=24）,secretory phase endometrium group （n=21）,non-functional endometrial polyps group （n=24）,simple hyperplasia group （n=24）,complex hyperplasia group （n=26） and endometrial carcinoma group （n=123）. Immunohistochemistry detection with EliVision method was performed. Results Different CA125 levels were found in normal and different pathological endometrial tissues. In proliferative phase endometrium group and secretory phase endometrium group,expression of CA125 appeared to be weakly or moderately positive with no significant difference （P0.05）,while significant difference in positive CA125 expression was found among non-functional endometrial polyps group,simple hyperplasia group and complex hyperplasia group （χ2=9.652,P0.005）. In endometrial carcinoma group,the positive CA125 expression showed no significant difference between pathological grade Ⅰ and grade Ⅱ （χ2=3.698,P0.05）,while significant difference was found when pathological grade Ⅰ and Ⅱ was compared with grade Ⅲ （χ2=11.975,P0.01）. Conclusion CA125 expression in normal and pathological endometrial tissue is in accordance with the status pathological process.

关 键 词：CA-125抗原 子宫内膜 子宫内膜肿瘤 免疫组织化学 

分 类 号：R711.32[医药卫生—妇产科学]