microRNA对免疫系统发育和应答的调节作用  

Function of microRNAs in development of immune system and in regulation of immune response

作　　者：陈青云[1] 王青青[1] 

机构地区：[1]浙江大学医学院免疫学研究所,浙江杭州310058

出　　处：《浙江大学学报（医学版）》2010年第3期326-332,共7页Journal of Zhejiang University(Medical Sciences)

基　　金：国家自然科学基金资助项目(NO:30872377)

摘　　要：microRNA(miRNA)是调节生物体发育的有效分子,表现为对基因的微量调节。现有的证据表明miRNA参与天然免疫和适应性免疫应答的调节,这种调节与免疫系统发挥作用有十分密切的关系。因此,对miRNA的研究有助于对人类免疫系统调节机制更深入地了解,建立基于miRNA的有效疗法。microRNAs function as effective molecules in regulation of many biological functions of organisms;in most case they regulate gene expression moderately.Emerging evidence suggests that microRNAs play a key role in the regulation of immunological functions including innate and adaptive immune responses.The research on microRNAs would be helpful in elucidation of the mechanisms of human immune system and in development of potential therapies based on microRNAs.

关 键 词：微RNAs/生理学 免疫系统 基因表达调控 

分 类 号：R392.1[医药卫生—免疫学]