组织工程化脂肪的构建与应用  

Construction and application of tissue-engineered adipose tissue

作　　者：李东君[1] 贾全章 

机构地区：[1]延边大学医学院,吉林省延吉市133000 [2]解放军第二○八医院脊柱外科,吉林省长春市130062

出　　处：《中国组织工程研究与临床康复》2010年第11期2018-2021,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：背景:软组织缺损的修复是整形外科的重要难题,而目前用于临床治疗的各种方案都存在一定缺陷。目的:对脂肪组织工程的研究现状进行相应的探讨,分析目前所采用方案的缺陷,并对其将来可能的临床应用进行相应展望。方法:以adipose tissue engineering,mesenchymal stem cells,derived from adipose tissue为检索词,检索Medline数据库(1991-01/2009-05);以脂肪,组织工程,间充质干细胞为检索词,检索中国期刊全文数据库(1991-01/2009-05)。文献检索语种限制为英文和中文。纳入与组织工程化脂肪组织构建相关的内容,排除重复研究。结果与结论:计算机初检得到342篇文献,根据纳入排除标准,对33篇进行分析。在探索软组织缺损治疗方法的过程中发现:组织工程技术能以少量种子细胞,经体外扩增后与生物材料复合,修复较大的组织或器官缺损,重建生理功能,为真正实现无损伤修复组织缺损和真正意义上的形态、结构与功能重建开辟了新的途径。当前已有多种成功构建脂肪组织的策略用于治疗软组织缺损,这将给填充脂肪组织修复软组织缺损开辟广阔的天空。BACKGROUND： Soft-tissue defect in plastic surgery is a major problem, and currently all of methods used for clinical treatment have certain shortcomings. OBJECTIVE： To investigate the research status of adipose tissue engineering, to analyze the current deficiencies in the application of the program, and to outlook its possible future in clinical application. METHODS： A computer-based online search was conducted in Medline and CNKI with the key words of ＂adipose tissue engineering, mesenchymal stem cells, derived from adipose tissue＂ in both Chinese and English from January 1991 to May 2009. The related articles about fat tissue and tissue-engineered building were included, but the duplicated studies were excluded. RESULTS AND CONCLUSION： A total of 342 documents were retrieved firstly. According to the inclusion criteria, 33 articles were included in the final analysis. During the exploration of treatment for soft-tissue defect, tissue engineering technology provided a new method by combining the seed cells amplifying in vitro with biomaterial to repair some tissue or organ defects, reconstruct physiological function, and finally to achieve the ultimate goal of non-damage repairment of organic defect and reconstruction of morphology, structure and function. Nowadays there are several successful strategies of constructing adipose tissue in treatment for soft tissue defect, which will fill in the blanks in the repairment of adipose tissue defect.

关 键 词：组织工程脂肪 乳房再造 间充质干细胞 软组织缺损 脂肪干细胞 综述文献 

分 类 号：R318[医药卫生—生物医学工程]