92例甲状腺癌中细胞增殖蛋白表达及其意义  

Expression of p53,PCNA,Ki-67 in thyroid carcinoma and its significance

作　　者：王凤华[1] 宋晶莹[1] 

机构地区：[1]解放军第309医院病理科,北京100091

出　　处：《现代肿瘤医学》2010年第6期1102-1103,共2页Journal of Modern Oncology

摘　　要：目的:探讨甲状腺癌组织中p53、PCNA和Ki-67蛋白表达及其与临床病理的关系。方法:应用免疫组化SP法对92例甲状腺癌组织中p53、PCNA和Ki-67蛋白进行检测。结果:甲状腺癌组织p53阳性表达率为54.3%(50/92),PCNA阳性表达率为56.9%(52/92),Ki-67增殖指数为(12.01±3.32)%。p53、PC-NA过度表达及Ki-67增殖指数增加与浸润程度及淋巴结转移有关。结论:p53、PCNA和Ki-67蛋白表达与癌的浸润程度及淋巴结转移有关,p53、PCNA和Ki-67联合检测对甲状腺癌的早期诊断、预后判断及制定合理的临床治疗方案有重要意义。Objective：To investigate the relationship among the expression of p53, PCNA and Ki -67 proteins and clinieopathology of human thyroid carcinoma. Methods： Using SP immunohistochemieal methods, the expression of p53, PCNA and Ki -67 proteins was detected in 92 cases of thyroid carcinoma. Results：The positive rate of p.53 pro- tein expression was 54.3% （ 50/92 ） , PCNA was 56.9% （ 52/92 ） , and Ki - 67 proliferative index was （ 12.01 ± 3.32）% in thyroid carcinoma. A significant correlation was found among p53, PCNA expression and Ki -67 over expression and the depth of invasion and lymph node metastasis. Condusion：A significant correlation was found among p53,PCNA expression and Ki - 67 over expression and the depth of invasion and lymph node metastasis of cancer. The abnormal expression of p53, PCNA, Ki - 67 has an important clinical value for early diagnosis, prognosis evaluation and proper treatment of thyroid carcinoma.

关 键 词：P53 PCNA KI-67 甲状腺癌 免疫组化 

分 类 号：R763.1[医药卫生—耳鼻咽喉科]