超声评价稳定型心绞痛患者颈总动脉结构及功能与肱动脉血管内皮功能的关系  

Relationship between brachial artery endothelial function and common carotid arterial hemodynamics and structure in patients with stable angina evaluated by ultrasonography

作　　者：李进兵[1] 熊昌林 冯靖禧[3] 陈伯钧[3] 沈嫱[1] 石小红[1] 

机构地区：[1]广州中医药大学附属第二医院超声科,广州市510120 [2]河南省郑州航海医院影像科 [3]广州中医药大学附属第二医院心内科,广州市510120

出　　处：《临床超声医学杂志》2010年第5期305-308,共4页Journal of Clinical Ultrasound in Medicine

摘　　要：目的探讨稳定型心绞痛患者肱动脉内皮功能与颈总动脉血流动力学、结构的改变及其相互关系。方法 30例稳定型心绞痛患者和20例健康者对照组,超声检测并计算血流介导的肱动脉血管舒张功能(FMD)和硝酸甘油介导的肱动脉血管舒张功能(NMD),颈总动脉内中膜复合体厚度(IMT)、弹性指数(Ep)、僵硬指数(β)及最大剪切率。结果与对照组比较,稳定型心绞痛组FMD降低,颈总动脉IMT增厚,Ep指数、β指数增高,最大剪切率降低,差异均有统计学意义(P<0.01)。稳定型心绞痛FMD与颈总动脉IMT(r=-0.69,P<0.01)、Ep指数(r=-0.48,P<0.01)、β指数(r=-0.54,P<0.01)呈负相关,与最大剪切率(r=0.57,P<0.01)呈正相关。结论稳定型心绞痛患者颈动脉血流动力学及结构改变与肱动脉血管内皮功能的变化相关。Objective To explore the changes of brachial artery endothelial function, common carotid arterial hemodynamic and structure in patients with stable angina, and to analyze their relationship. Methods Thirty patients with stable angina and twenty healthy subjects were enrolled in this study. The intima - media thickness （IMT） of common carotid artery, pressure strain elastic modulus （Ep）, pressure independent stiffness index （β） and shear rate （SR） were measured by uhrasonography, flow - mediated dilation （ FMD ） and Nitroglycerin - mediated dilation （NMD） in the brachial artery were evaluated. Results Compared with control group, FMD in stable angina group was decreased,the IMT of common carotid artery was thicker,Ep and β were increased,while SR was decreased in stable angina group （P 〈0.01 ）. FMD of stable angina group was negatively correlated with IMT （ r = - 0.69, P 〈 0.01 ）, β （ r = - 0.54, P 〈 0.01 ） and the Ep （ r = - 0.48, P 〈 0.01 ） of common carotid artery. There was positive correlation between the FMD and the SR （ r = 0.57, P 〈 0.01 ） of common carotid artery. Conclusion The common carotid arterial hemodynamic and structure are related with the brachial artery endothelial function in patients with stable angina.

关 键 词：超声检查 稳定型心绞痛 内皮功能 颈总动脉 

分 类 号：R445.1[医药卫生—影像医学与核医学]