高敏C反应蛋白对新发脑出血风险的预测价值  

The risk predictive value of high sensitivity C-reactive protein level for new hemorrhagic stroke events

作　　者：朱婕[1] 吴寿岭[2] 王艳秀[2] 王剑利[2] 赵洪涛[2] 侯国盛[2] 李冬青[2] 金成[2] 李金锋[1] 邸艳荣[2] 

机构地区：[1]华北煤炭医学院,唐山063000 [2]华北煤炭医学院附属开滦医院心内科

出　　处：《中华内科杂志》2010年第6期469-472,共4页Chinese Journal of Internal Medicine

摘　　要：目的 探讨基线血清高敏C反应蛋白（hs-CRP）水平对新发脑出血风险的预测价值.方法 采用回顾性巢式病例对照研究方法,选择观察队列中新发脑出血患者323例,对照组646例.比较两组组间基线hs-CRP水平,分析不同基线hs-CRP水平对新发脑出血的风险.结果 新发脑出血患者基线hs-CRP水平（1.10 mg/L）高于对照组（0.66 mg/L,P〈0.01）;hs-CRP四分位数水平较高者（〉2.12 mg/L）新发脑出血的风险是较低者（≤0.30 mg/L）的2.58倍（95%CI 1.77～3.76,P〈0.01）;对hs-CRP以3 mg/L及以第八十百分位点为临界值分组后进行统计分析,hs-CRP与新发脑出血风险的相关性依然存在,OR值分别为2.26（95%CI 1.60～3.20,P〈0.01）和2.24（95%CI 1.60～3.13,P〈0.01）.结论 基线hs-CRP水平对新发脑出血有预测价值,基线hs-CRP水平较高者新发脑出血风险增加.Objective To study the risk prediction for new intracerebral hemorrhage （ICH） with high sensitivity C-reactive protein （ hs-CRP） level. Methods In a retrospective, nested, case-controlled study, 323 cases of ICH were identified and matched with 646 controls. The hs-CRP levels at baseline were compared between the two groups. The relevance of different hs-CRP levels and the risk of ICH were analyzed. Results The ICH group had a higher median hs-CRP levels （1.10 mg/L） as compared with the control group （0. 66 mg/L） with significant difference （ P〈0.01 ）. In addition, the increase of risk associated with hs-CRP levels was primarily observed in the individuals with the highest quartile of hs-CRP levels（〉2.12 mg/L）. These patients had an increased risk of ICH （OR 2. 58, 95% CI 1. 77 to 3. 76） as compared with those in the lowest quartile（≤=0.30 mg/L）. Individuals with basiline hs-CRP levels above the specified cut point of 3 mg/L ormore and those in the 80th percentile were at a markedly increased risk of ICH （for specified cut point of 3 mg/L,0R2.26, 95% CI 1.60-3.20, P〈0.01; for 80th percentile, OR 2.24,95% CI 1.60-3.13, P 〈0.01, respectively）. Conclusions Risk of ICH might be predicted with the level of hs-CRP. With the increase of hs-CRP level at baseline, the risk of ICH was increased.

关 键 词：C反应蛋白 脑出血 病例对照研究 

分 类 号：R541.4[医药卫生—心血管疾病]