江苏南通地区变应性鼻炎与支气管哮喘患病相关性的遗传流行病学研究  

A related heredity epidemiological research on allergic rhinitis and asthma in Nantong region

作　　者：马莉[1] 陈大灵 章如新[3] 汪晓雷[1] 施云剑 季超[1] 黄志俊[1] 钱茂华[1] 高刚[1] 黄永娟[1] 管沛[1] 

机构地区：[1]南通大学第二附属医院耳鼻咽喉科,226001 [2]南通市疾控中心慢病科 [3]复旦大学附属华东医院耳鼻咽喉科

出　　处：《中华耳鼻咽喉头颈外科杂志》2010年第6期502-505,共4页Chinese Journal of Otorhinolaryngology Head and Neck Surgery

基　　金：江苏省卫生厅重点资助科研项目（H9929S9918）

摘　　要：目的 探讨江苏省南通地区遗传因素对变应性鼻炎及支气管哮喘患病相关性的影响.方法 按随机抽样法,对本地区95 300人进行了变应性鼻炎和支气管哮喘患病相关性遗传流行病学的调查研究.人群患病情况采用SPSS11.5进行卡方检验,遗传度采用Falconer公式计算.结果 变应性鼻炎患者并发支气管哮喘的比例为25.92%（296/1142）,支气管哮喘患者并发变应性鼻炎的比例为40.49%（296/731）.变应性鼻炎患者Ⅰ、Ⅱ、Ⅲ三级亲属支气管哮喘的患病率分别为8.19%（280/3418）、3.08%（154/5002）及3.16%（85/2687）;支气管哮喘患者Ⅰ、Ⅱ、Ⅲ三级亲属变应性鼻炎的患病率分别为15.81%（466/2947）、4.61%（229/4967）及2.51%（134/5345）,均高于一般人群支气管哮喘及变应性鼻炎患病率（分别为1.20%和0.77%,P〈0.05）.支气管哮喘患者三级亲属变应性鼻炎患病的加权平均遗传度（（x）±s,以下同）为94.2%±1.9%;变应性鼻炎患者三级亲属支气管哮喘患病的加权平均遗传度为81.8%±2.1%,均大于60%,二者患病相关性与遗传高度相关.结论 支气管哮喘与变应性鼻炎患病具有明显相关性,与多基因遗传有关,支持二者是同一气道,同一疾病的学说.Objective To discuss the related impact of genetic factors in the incidence of bronchial asthma （ BA） and allergic rhinitis （ AR） in Nantong region, China. Methods By random sampling method, investigation and research on the incidence of genetic epidemiology were carried out in the population of 95 300 on AR and BA. Results The rate of patients with allergic rhinitis with asthma was 25.92% （296/1142）, the rate of asthma patients with allergic rhinitis was 40.49% （296/731）. The prevalences of AR complicated with BA were 8.19% （280/3418）, 3.08% （154/5002） and 3.16% （85/2687） in the first-, second-and third-degree relatives of the probands respectively, while the prevalences of BA complicated with AR were 15.81% （466/2947）, 4.61% （229/4967） and 2.51% （134/5345） in the first-,second- and third-degree relatives of the probands respectively, higher than those in the controls （P 〈 0. 05）. The weighted mean heritability of AR in BA patients was 94. 2% ±1.9%, while the weighted mean heritability of BA in AR patients was 81. 8% ±2. 1% , more than 60% , suggesting that both AR and BA were relevant with genetics. Conclusions The incidence of BA and AR has obvious relevance, supporting the theory that the two diseases are an united airway disease and relevant with polygene heredity.

关 键 词：鼻炎 变应性 哮喘 流行病学因素 遗传筛查 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]