骨性关节炎生物学标记物软骨寡聚基质蛋白的研究进展  

RESEARCH PROGRESS OF CARTILAGE OLIGOMERIC MATRIX PROTEIN

作　　者：白伦浩[1] 王瑜[1] 张田鹏[1] 

机构地区：[1]中国医科大学附属盛京医院脊柱关节科,沈阳110001

出　　处：《中国修复重建外科杂志》2010年第6期714-717,共4页Chinese Journal of Reparative and Reconstructive Surgery

摘　　要：目的综述骨性关节炎(osteoarthritis,OA)生物学标记物软骨寡聚基质蛋白(cartilage oligomeric matrix protein,COMP)的研究进展。方法广泛查阅近年来关于COMP的文献,并对其进行分析。结果 COMP是目前广泛研究的OA生物学标记物之一,研究认为COMP与OA的发生、发展具有相关性,是目前所研究的生物标记物中可以持续表达并预测进程的最佳标记物。结论 COMP在OA发病机制中的确切作用仍不清楚,采用COMP作为手段早期诊断OA需进一步深入研究。Objective To review the research progress of cartilage oligomeric matrix protein（COMP）.Methods Domestic and abroad literature about COMP was reviewed and summarized.Results COMP was one of the osteoarthritis（OA） biomarkers of being widely studied.Most studies in recent years could draw the conclusion that COMP was associated with OA.COMP was the foremost biomarker among investgated biomarkers.It could been continuously expressed and predicted knee OA progression.Conclusion Precisely what role COMP plays in OA pathogenesis remains unclear,using COMP as a tool to early diagnose OA more studies would be needed.

关 键 词：软骨寡聚基质蛋白 骨性关节炎 生物标记物 

分 类 号：R684.3[医药卫生—骨科学]