纳米羟基磷灰石直接盖髓诱导牙本质桥早期形成的可行性  

Feasibility of early dentine bridge formation induced by direct pulp capping with nano-hydroxyapatite

作　　者：邱伟 时咏梅 徐进云 

机构地区：[1]大连市口腔医院,辽宁省大连市116021

出　　处：《中国组织工程研究与临床康复》2010年第21期3869-3872,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：背景:传统的盖髓剂主要是氢氧化钙,强碱性,对牙髓组织刺激性强,不具有长期有效的封闭效应,随着时间的推移,氢氧化钙会发生溶解,形成微渗漏,使细菌得以入侵。目的:观察纳米羟基磷灰石直接盖髓诱导牙本质桥早期形成。方法:将深龋去腐质露髓门诊患者98例113颗患牙随机分为两组,氢氧化钙组用氢氧化钙行直接盖髓,纳米羟基磷灰石组用纳米羟基磷灰石行直接盖髓,盖髓后6周,6个月和1年对比两组髓腔及根周组织情况。结果与结论:氢氧化钙与纳米羟基磷灰石直接盖髓早期牙本质桥形成差异无显著性意义(P>0.05),盖髓后1年纳米羟基磷灰石有助于牙本质桥早期形成(有牙本桥形成:成功率90%,无牙本桥形成:成功率65%),作为盖髓剂具有可行性。BACKGROUND：Conventionally,pulp capping materials,mainly calcium hydroxide,have strong alkalinity and strong stimulation to pulp tissue without a long-term sealing effect.With the time going,calcium hydroxide dissolves,and micro-leakage forms,so that bacteria may invade.OBJECTIVE：To observe the early formation of dentine bridges following direct pulp capping with nano-hydroxyapatite.METHODS：A total of 113 teeth from 98 patients with exposed points of dental pulp were divided randomly into two groups.One group was treated with direct pulp capping with calcium hydroxide,while the other group was treated with direct pulp capping with nano-hydroxyapatite.Clinical observations were made after six weeks,six months and one year after treatment respectively.Treating effects of the two groups were compared and pulp cavity and periapical change were observed.RESULTS AND CONCLUSION：There was no difference in early formation of dentine bridge between treating with calcium hydroxide and with nano-hydroxyapatite（P 0.05）.Nano-hydroxyapatite contributes to the early formation of dentine bridge at 1 year following pulp capping（The clinical success rate was 90% for dentine bridge formation,whereas 65% for non-formation）,and it can be used as pulp capping materials.

关 键 词：纳米羟基磷灰石 直接盖髓 牙本质桥 氢氧化钙 修复材料 牙周与口腔组织再生修复材料 

分 类 号：R318[医药卫生—生物医学工程]