人工韧带表面修饰重建前交叉韧带的系统评价  

A systematic assessment on surface modified artificial ligament for anterior cruciate ligament reconstruction

作　　者：周玉坤[1] 彭鸿灵 

机构地区：[1]贵阳医学院附属医院骨科,贵州省贵阳市550000 [2]四川大学华西临床医学院,四川省成都市610041

出　　处：《中国组织工程研究与临床康复》2010年第21期3965-3968,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：目的:探讨人工韧带表面修饰重建前交叉韧带的安全性和有效性。方法:以"人工韧带,支架材料,交叉韧带,重建"为检索词在中国期刊全文数据库(CNKI:1990/2010)中采用电子检索方式进行文献检索。对体外研究和动物实验进行归纳分析,对临床对比研究采用Review Manager 4.2软件进行分析。结果:从16篇体外研究文献中选出5篇,显示各种形式的表面修饰能使人工韧带达到良好的生物学特性以及组织相容性。从19篇动物实验文献中选择4篇,实验结果显示表面修饰的人工韧带在动物体内同样能发挥生物功能达到恢复关节功能的目的。从57篇临床分析的文献中选取5篇对比研究,采用Meta分析结果显示,人工韧带重建组与非人工韧带重建组存在差异,但并不具有显著性意义(P=0.40),5篇文献实验的RR值和95%CI分别为1.10(-1.01,3.21),6.80(4.10,9.50),-0.66(-1.16,0.16),8.06(5.17,10.95)和4.18(2.48,5.88),合并后的RR值和95%CI为0.20(-0.26,0.65)。结论:人工韧带表面修饰重建前交叉韧带具有良好的组织相容性和安全性,且能获得与同种异体或自体移植相似的临床效果。OBJECTIVE：To investigate the safety and effectiveness of artificial ligament surface modification in anterior cruciate ligament reconstruction.METHODS：Using ＂artificial ligament,scaffolds,cruciate ligament,reconstruction＂ as the search word,an electric retrieval was performed in the Chinese Journal Full-text database（CNKI：1990/2010）.In vitro studies and animal experiments were summarized and analyzed,clinical comparative study was analyzed using Review Manager4.2 software.RESULTS：Five out of 16 in vitro studies were involved in the analysis,showing various forms of surface modification can achieve good biological properties and tissue compatibility of artificial ligament.Four out of 19 animal experiments show that,surface modified artificial ligaments also exhibit biological functions in animals and then achieve the goal of joint function restoration.Five out of 57 clinical comparative analysis were demonstrated by Meta analysis,there were differences between the artificial ligament reconstruction group and the non-artificial ligament reconstruction group,but not statistically significant（P = 0.40）,the RR value and 95%CI of 5 test articles were 1.10（-1.01,3.21）,6.80（4.10,9.50）,-0.66（-1.16,0.16）,8.06（5.17,10.95）,4.18（2.48,5.88）,respectively,the combined RR values and 95%CI was 0.20（-0.26,0.65）.CONCLUSION：The surface modified artificial ligament shows good biocompatibility and safety for anterior cruciate ligament reconstruction,and can obtain similar clinical effects in allogeneic or autologous transplantation.

关 键 词：人工韧带 表面修饰 系统评价 前交叉韧带 组织相容性 

分 类 号：R318[医药卫生—生物医学工程]