IL-17在子痫前期患者胎盘组织和外周血中的表达  

Expression of interleukin-17 in placenta and peripheral blood of patients with preeclampsia

作　　者：田美荣[1] 马玉燕[1] 王磊一[2] 范月莲[1] 刘振平[2] 

机构地区：[1]山东大学齐鲁医院妇产科,济南250012 [2]山东大学齐鲁医院基因室,济南250012

出　　处：《山东大学学报（医学版）》2010年第5期105-107,112,共4页Journal of Shandong University:Health Sciences

摘　　要：目的探讨白细胞介素-17(IL-17)和Th17细胞与子痫前期发病的关系。方法选取32例重度子痫前期患者为子痫前期组,30例正常晚期妊娠孕妇为对照组。采用实时定量PCR方法检测两组胎盘组织IL-17mRNA表达水平;酶联免疫吸附试验双抗体夹心(ELISA)法检测外周血血清IL-17、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)的浓度。结果子痫前期组胎盘IL-17mRNA表达量较对照组升高(P<0.05);子痫前期组外周血血清IL-17、IL-6、TNF-α水平均高于对照组(P<0.01、P<0.05、P<0.01);子痫前期组外周血中IL-17与IL-6的表达水平呈正相关(r=0.402,P<0.05)。结论 IL-17和Th17细胞介导了子痫前期的发生,其过程可能与IL-6和TNF-α的参与有关。Objective To investigate the relationship of IL-17 and Th17 cells with preeclampsia.Methods Thirty-two patients with severe preeclampsia and thirty normal pregnant women as controls were investigated.① Expression of IL-17 mRNA in placental specimens was detected by real-time PCR;② Concentrations of IL-17,IL-6 and TNF-α in the serum were measured by ELISA.Results Compared with the control group,expression of IL-17 mRNA was higher in preeclampsia placentas（P0.05）;levels of IL-17,IL-6 and TNF-α in maternal serum were higher in the preeclampsia group than in the controls（P0.01,P0.05,P0.01 respectively）;and in the preeclampsia group,there was a positive correlation between IL-17 and IL-6（r=0.402,P0.05）.Conclusions IL-17 and Th17 cells may contribute to the pathogenesis and patho-physiology of preeclampsia.IL-6 and TNF-α may also be involved in the process.

关 键 词：白细胞介素类 TH17细胞 子痫前期 肿瘤坏死因子-α 

分 类 号：R714.1[医药卫生—妇产科学]