盐酸戊乙奎醚对脑肿瘤病人脑氧代谢及s100b蛋白的影响  

Effect of Penehyclidine Hydrochloride on Cerebral Oxygen Supply/Consumption and Protein slOOb in Patients with Cerebral Tumor

作　　者：刘伟亮[1] 孙能宏[1] 刘婷[1] 郎堡[1] 王伟芝[1] 

机构地区：[1]潍坊医学院附属潍坊市人民医院麻醉科,山东潍坊261041

出　　处：《潍坊医学院学报》2010年第2期107-109,共3页Acta Academiae Medicinae Weifang

摘　　要：目的 探讨盐酸戊乙奎醚对脑肿瘤病人脑氧代谢及s100b蛋白的影响.方法 选择ASA错误ASAⅠ或Ⅱ及择期手术病人60例,随机分为3组：盐酸戊乙奎醚0.02mg/kg（A组）,盐酸戊乙奎醚0.05mg/kg（B组）和安慰剂对照组（C组）.3组均采用复合全身麻醉,诱导前5min各组分别给予相应剂量的盐酸戊乙奎醚或安慰剂.分别于诱导前即刻（T1）、诱导后30min（T2）和手术结束前（T3）取动脉血和颈内静脉球血行血气分析,计算动脉血氧含量（CaO2）,颈内静脉血氧含量（CjvO2）,动静脉血氧含量差[C（a-jv） O2],脑氧摄取率（CERO2）,动静脉血乳酸浓度差VADL;并测定T1,T2和T3时点颈内静脉血血清s100B蛋白和NSE含量.结果 3组病人各时点CaO2无统计学差异.A,B组CjvO2,C（a-jv） O2,VADL在T2,T3时刻与T1比较有统计学意义（P〈0.05）,且与同时刻C组比较均有显著差异（P〈0.05）.A,B组CERO2在T2,T3时刻与T1比较有统计学意义（P〈0.05）.3组在T2,T3时刻血清S100B蛋白和NSE含量较T1均明显升高（P〈0.05）,且C组升高最为显著（P〈0.01）;在T2,T3时刻A,B组与同时刻C组比较,血清S100B蛋白和NSE含量变化均有统计学意义（P〈0.05）.结论 盐酸戊乙奎醚可明显改善脑组织缺氧,提高氧摄取率,维持脑氧供需平衡,减轻术后脑损伤程度,具有脑保护作用.Objective To investigate the effect of Penehyclidine Hydrochloride on cerebral o2 supply/consumption and protein s100b in patients with cerebral tumor. Methods Sixty ASA I or II patients undergoing elective surgery were randomly divided into 3 groups. The patients in the three groups were given combined anesthesia. Five minutes before anesthesia induction, group A was injected Pene- hyelidine Hydrochloride（0.02mg/kg） ,group B was injected Penehyclidine Hydrochloride （0.05mg/kg） ,while group C was injected placebo. Blood samples were taken for blood gas analysis from artery（ a） and jugular venous bulb（jv） simultaneously before anesthesia induction （T1 ） ,30min after anesthesia induction（T2） and before conclusion of operation. Arterial oxygen content,arterial-jugular bulb venous O2 content difference （ Da-jvO2 ） , cerebral O2 extraction rate （ CERO2 ） and arterial-jugular bulb venous lactate difference （VADL） were calculated. At the same time, protein s100b and NSE were detected. Results In group A and B, the level of CjvO2 on T2 and T3 was higher than that of on T1 （ P 〈 0.05 ）. Compared with group C, CERO2 , Protein s100b and NSE of three groups on T2 and T3 were higher than that of on T1 （ P 〈 0.05 ） , and group C had the highest level（ P 〈 0.01 ）. Compared with group C ,the level of Protein s100b and NSE of group A and B was lower on T2 and T3 （ P 〈 0.05 ）. Conclusion Penehyclidine Hydrochloride can increase cerebral O2 supply and extraction rate. Penehyclidine Hydrochloride has effect on cerebral protection.

关 键 词：盐酸戊乙奎醚 脑肿瘤 S100B蛋白 

分 类 号：R971.92[医药卫生—药品]