单肺通气早期七氟醚肺摄取的临床研究  

Clinical Study on Pulmonary Uptake of Sevoflurane during Early Stage in One-Lung Ventilation

作　　者：张涣君[1] 王伟芝[2] 罗艳华[2] 纪凡层[2] 王绍明[2] 

机构地区：[1]潍坊医学院麻醉学系,山东潍坊261041 [2]潍坊医学院附属潍坊市人民医院麻醉科

出　　处：《潍坊医学院学报》2010年第2期142-144,共3页Acta Academiae Medicinae Weifang

摘　　要：目的 观察比较七氟醚在单肺通气（OLV）和双肺通气（TLV）早期吸入过程中的肺摄取情况及对麻醉深度的影响.方法 全身麻醉下行食道肿瘤切除术病人30例,随机分成OLV组和TLV组,均于全麻诱导后插入双腔支气管导管行控制呼吸,OLV组于术者打开胸壁时开始行右侧单肺通气,TLV组保持双肺通气不变.七氟醚吸入后记录每组病人各个时点的SpO2,MAP,HR,BIS、七氟醚吸入气浓度（FI）和呼出气浓度（ET）并计算ET/FI.结果 两组间SpO2,MAP,HR,BIS相比差异均无显著性 （P〉0.05）,两组间FI差异均无显著性（P〉0.05）,OLV组ET高于TLV组（P〈0.05）,ET/FI高于82.5%TLV组（P〈0.05）.结论 OLV早期对七氟醚的肺摄取速率高于同期TLV,两组患者BIS反映的麻醉深度无明显差别.Objective To investigate the intake of sevoflurane and its influence on depth of anesthesia during early stage in one-lung （OLV ） and two-lung ventilation （ TLV ）. Methods Thirty patients undergoing esophageal cancer resection were randomly divided into OLV-group and TLV-group. After induction of general anaesthesia,doublelumen endobronchial tube was inserted to control breath. SpO2 , MAP, HR, BIS, the concentration of inspired sevoflurane （FI） and of expired sevoflurane（ET） on each time point was recorded and ET/FI was calculated. Results There was no significant difference in SpO2 , MAP, HR, BIS and FI on each time point between the two groups （ P 〉 0.05 ） ; ET of the OLV-group was higher than that of the TLV-group（P 〈 0.05）. ET/FI of OLV group was also higher than 82.5% TLV group （ P 〈 0.05 ）. Conclusion In the early period of sevoflurane intake, the pulmonary uptake rate of sevoflurane in OLV was higher than that in TLV. There was no significant difference in depth of anesthesia reflected by BIS between the two groups.

关 键 词：单肺通气 七氟醚 肺摄取 BIS 

分 类 号：R61[医药卫生—外科学]