增强型体外反搏对冠心病患者血清血管内皮生长因子的影响——附31例检测分析  

The effect of enhanced extracorporal counterpulsation on serum vascular endothelial growth factor in patients with coronary heart disease.

作　　者：钱孝贤[1] 吴伟康[1] 郑振声[1] 余步云[1] 张苗青[1] 赵顺卿[1] 陈国庆[1] 

机构地区：[1]中山医科大学卫生部辅助循环重点实验室 [2]中山医科大学第三临床学院心内科 [3]中山医科大学病理生理教研室

出　　处：《新医学》1999年第1期9-10,57,共3页Journal of New Medicine

基　　金：国家自然科学基金;广东省卫生厅科研基金

摘　　要：目的：探讨增强型体外反搏对冠心病患者血清血管内皮生长因子（ＶＥＧＦ）的影响。方法：采用酶联免疫吸附测定法检测３１例冠心病患者和３４名正常人血清中ＶＥＧＦ水平，并观察冠心病患者在增强型体外反搏治疗过程中及反搏后血清ＶＥＧＦ的动态变化。结果：治疗前，冠心病患者血清ＶＥＧＦ含量（２７２±１４２）ｎｇ／Ｌ明显高于正常人（１２２±３０）ｎｇ／Ｌ，Ｐ＜０．００１。在体外反搏治疗第一疗程末患者血中ＶＥＧＦ水平明显降低，但在随后的两个疗程中ＶＥＧＦ又有一定程度的增高，但仍低于反搏前水平。结论：本研究从ＶＥＧＦ的角度发现体外反搏可改善冠心病患者的心肌缺血。Objective:To investigate the effect of enhanced extracorporal counterpulsation(EECP)on serum vascular endothelial growth factor(VEGF)in patients with coronary heart disease(CHD) Methods:The serum VEGF levels of 31 CHD patients and 34 cases of control were determined by enzyme linked immunosorbent assay Before,during and after EECP treatment Results:The serum VEGF levels in patients with CHD were much higher than that in control subjects(272±142 vs 122±30 ng/L, P <0 001).The serum VEGF levels of CHD patients decreased remarkably after 1 course of EECP treatment.However the concentrations of VEGF increased slightly after 2～3 courses of treatment.Conclusion:The results suggest that EECP treatment may improve myocardial perfusion in patients with CHD,and may also exert an effect on serum VEGF level.

关 键 词：反搏动术 VEGF 冠心病 体外反搏 

分 类 号：R541.4[医药卫生—心血管疾病]