Synthesis and Mollucicidal Activity of Some New Bicyclic and Polycyclic Pyrimidine Derivatives  

作　　者：Mohamed Abdel-Megid Mohamed Abdel-Hamid Awas Magdy Seada Kamelia Mohamed Elmhdy Mortta Mohamed Elsayed 

机构地区：[1]Chemistry Department, Faculty of Education, Ain Shams University Roxy, Cairo I1711, Egypt [2]Environmental Research Laboratory, Theodor Bilharzias Research Institute, Giza 10115, Egypt

出　　处：《Journal of Chemistry and Chemical Engineering》2010年第5期41-53,共13页化学与化工（英文版）

摘　　要：Hydrazinolysis ofethylthiopyrimidine derivative 2 gave 2-hydrazinopyrimidine 3 which used as a convenient precursor for the synthesis of pyrazolylpyrimidines, hydrazones and pyrimidotriazines. Also, treatment of 2 with ethyl chloroacetate yielded N^-carbethoxymethyl-2-ethylthio-pyrimidine 15, which on reaction with ethyl carbazate and hydrazine hydrate afforded pyrimidotriazine and imidazopyrimidine, respectively. Chlorination of 2 using phosphorous oxycbloride yielded 4-chloropyrimidine 18, which reacted with some heterocyclic compounds having vicinal amino cyano groups to give some new polynuclear heterocyclic system. Also, the effect of some active methylene compounds on 18 was also studied. Some of the newly synthesized compounds were tested as mollucicidal agents against Biomphlaria alexandrina snails that caused intestinal bilharzias, the national problem in Egypt.

关 键 词：Pyrazolylpyrimidines pyrimidotriazines imidazopyrimidines pyrimidopyrimidines mollucicidal activity. 

分 类 号：TQ225.3[化学工程—有机化工] S831.5[农业科学—畜牧学]