参蛤散联合西药治疗心肾阳虚型充血性心力衰竭临床观察  被引量:18

Clinical observation of "Ginseng-Gecko Powder" in treating congestive heart failure

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作  者:张伟珍[1] 章怡祎[1] 周端[1] 周时高[1] 陈伟[1] 

机构地区:[1]上海中医药大学附属龙华医院,上海200032

出  处:《上海中医药杂志》2010年第6期59-61,共3页Shanghai Journal of Traditional Chinese Medicine

基  金:上海市浦东新区科技发展基金课题(303-04-01-04)

摘  要:目的观察参蛤散联合西医常规疗法治疗心肾阳虚型充血性心力衰竭的临床疗效。方法将60例心肾阳虚型充血性心力衰竭患者随机分为两组,对照组(30例)予西医常规抗心力衰竭治疗,治疗组(30例)在西医常规治疗基础上加服参蛤散,两组疗程均为8周;观察治疗前后中医证候积分变化,用B超检测左室射血分数(LVEF)、每搏量(SV)、心输出量(CO)、E/A值,测定血清BNP水平,并评价临床疗效。结果治疗组、对照组的心功能疗效总有效率分别为86.67%、46.67%,组间疗效差异有统计学意义(P<0.01)。两组治疗后,中医证候积分、BNP水平均较治疗前下降(P<0.05,P<0.01),且治疗组治疗后证候积分、BNP水平均低于对照组(P<0.01)。治疗后两组LVEF、SV、CO均改善(P<0.05),且治疗组治疗后LVEF、SV、CO、E/A值改善优于对照组(P<0.05,P<0.01)。结论参蛤散结合西医基础治疗能有效改善心肾阳虚型充血性心力衰竭患者心功能,其机制可能与抑制血清BNP水平相关。Objective To investigate the clinical effects of "Ginseng-Gecko Powder" on congestive heart failure(CHF). Methods Sixty patients with CHF were randomly divided into two groups: control group was treated with conventional western therapy, and treatment group received conventional therapy combined with "Ginseng-Gecko Powder". The treatment course was eight weeks. At baseline and 8 weeks after treatment, the level of BNP in serum, score of TCM syndrome, and LVEF, SV, CO and E/A were detected. Results The total effective of cardiac function in the treatment group and the control group were 86.67% and 46.67 % respectively, with a difference between them ( P 〈 0.01 ). After treatment, the scores of TCM syndrome and the levels of BNP in two groups were signifi- cantly decreased (P 〈0.05, P 〈0.01 ), with better results in the treatment group than in the control group(P 〈0.01 ). After treatment, the levels of LVEF, SV and CO were all improved in both groups( P 〈0.05 ) ; LVEF, SV, CO and E/A value in the treatment group were more significantly improved than those in the control group( P 〈0.05, P 〈 0.01 ). Conclusion "" Ginseng-Gecko Powder" combined with conventional western therapy can improve the cardiac function in CHF patients possibly by depressing BNP concentration.

关 键 词:充血性心力衰竭 中西医结合疗法 参蛤散 心脏功能 脑钠肽 

分 类 号:R541.61[医药卫生—心血管疾病]

 

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