祛风止动方对阿扑吗啡诱导抽动障碍大鼠行为学的影响  

Effects of "Qufeng Zhidong Decoction" on ethology in rats of tic disorders induced by apomorphine

作　　者：王树霞[1] 吴敏[1] 周亚兵[1] 张欣[1] 马碧涛[1] 

机构地区：[1]上海交通大学医学院附属新华医院中医科,上海200092

出　　处：《上海中医药杂志》2010年第6期95-98,共4页Shanghai Journal of Traditional Chinese Medicine

基　　金：上海市中医脑病临床优势专科建设(2008YSZK004);上海市科委中药现代化(09dZ19753000);上海市教委优秀青年教师基金(jdy08090)

摘　　要：目的观察祛风止动方对抽动障碍大鼠行为学的影响。方法清洁级SD大鼠应用阿扑吗啡(APO)诱导抽动障碍模型。APO用药3周后,将造模成功的大鼠分为模型组、中药组、西药组各8只,另设正常组8只。正常组以0.9%NaCl溶液(10ml/kg)腹腔注射4周,模型组继续予APO(2mg/kg)腹腔注射4周,中药组在模型组处理基础上给予祛风止动方(18.4g/kg)灌胃,西药组在模型组处理基础上给予氟哌啶醇(1mg/kg)灌胃,1次/d,连续4周。对模型大鼠进行刻板行为和开野实验的研究,评价药物疗效。结果①刻板行为:模型组刻板行为评分均高于正常组、中药组和西药组,而且在给药15min后差异有统计学意义(P<0.05);②开野实验:模型组大鼠穿越格子数、理毛次数、直立次数、粪便粒数各项结果与其余各组相比差异均有统计学意义,中药组和西药组的穿越格子数和理毛次数相比差异有统计学意义(P<0.05)。结论祛风止动方可显著降低APO诱导抽动模型大鼠的活动水平,增强其适应力。Objective To observe the effects of ＂Qufeng Zhidong Decoction＂ on ethology in rats of tic disorders.Methods Tic disorder was duplicated by apomorphine,and then treated by ＂Qufeng Zhidong Decoction＂ and Haloperidol.Stereotyped behaviour and open-field test were employed to evaluate the effects.Results Stereotyped behaviour： the score of stereotyped behaviour was higher in model group than in normal group,herbal group and control group（P0.05）;open-field test： there were great differences in all test results between model group and the other three groups,with better results in crossing locomotion and hair-combing frequency in herbal group than in control group（P0.05）.Conclusion ＂Qufeng Zhidong Decoction＂ can obviously diminish the activity and enhance the adaptivity of rats of tic disorders.

关 键 词：抽动障碍 阿扑吗啡 祛风止动方 刻板行为 开野实验 

分 类 号：R285.5[医药卫生—中药学]