Synthesis and anti-inflammatory activity of 2-substituted-((N,N-disubstituted)-1,3-benzoxazole)-5-carboxamides  

作　　者：Reena M kiran G Rajyalakshmi G Venkateshwa Rao J Sarangapani M 

机构地区：[1]Department of Pharmaceutical Chemistry,Talla Padmavati College of Pharmacy [2]Department of Pharmaceutical Chemistry,College of Pharmaceutical Sciences,Kakatiya University

出　　处：《药学学报》2010年第6期730-734,共5页Acta Pharmaceutica Sinica

摘　　要：A series of 2-substituted-((N,N-disubstituted)-1,3-benzoxazole)-5-carboxamides derivatives were synthesized by the reaction of 2-substituted-5-carbomethoxy benzoxazole with different secondary amines.The newly synthesized compounds were characterized on the basis of spectral(FT-IR,1H NMR,MS) & elemental analysis.All these compounds were screened for anti-inflammatory activity using carrageenan induced rat paw edema method.All of these compounds exhibited significant activity.Among the tested compounds Ve,Vg,Vf and Va were considered to have potent anti-inflammatory activity and was comparable with standard.A series of 2-substituted-（（N,N-disubstituted）-1,3-benzoxazole）-5-carboxamides derivatives were synthesized by the reaction of 2-substituted-5-carbomethoxy benzoxazole with different secondary amines.The newly synthesized compounds were characterized on the basis of spectral（FT-IR,1H NMR,MS） elemental analysis.All these compounds were screened for anti-inflammatory activity using carrageenan induced rat paw edema method.All of these compounds exhibited significant activity.Among the tested compounds Ve,Vg,Vf and Va were considered to have potent anti-inflammatory activity and was comparable with standard.

关 键 词：BENZOXAZOLE anti-inflammatory activity CARRAGEENAN 

分 类 号：R916[医药卫生—药学]