基于小鼠温度趋向行为学表征的左金丸及反左金丸寒热属性  

COLD or HOT natural attribute of Zuojinwan and Fanzuojinwan based on temperature tropism of mice

作　　者：杨宏博[1,2] 赵艳玲[1] 李宝才[2] 王伽伯[1] 李瑞生[3] 贾雷[1,4] 程丹红[1,4] 肖小河[1] 

机构地区：[1]解放军第三〇二医院解放军中药研究所,北京100039 [2]昆明理工大学生命科学与技术学院,云南昆明650224 [3]解放军第三〇二医院动物实验中心,北京100039 [4]成都中医药大学,四川成都610075

出　　处：《药学学报》2010年第6期791-796,共6页Acta Pharmaceutica Sinica

基　　金：国家重点基础研究发展计划(973计划)资助项目(2007CB5-12607);国家自然科学基金资助项目(30772740)

摘　　要：中药四性又称＂四气＂,是指药物寒、热、温、凉四种不同的药性,它反映了药物对人体阴阳盛衰、寒热变化的作用倾向。四性理论作为中医理论体系的重要组成部分,是在前人长期的医疗实践中,对各种药物的性质及其疗效不断深化认识的基础上,结合药物作用于人体的不同表现进行概括和总结而来。This study is to investigate the authenticity between COLD and HOT natural attribute in the famous Chinese medicine formulas——Zuojinwan（Coptis-Evodia 6：1） and Fanzuojinwan（Coptis-Evodia 1：6） based on mice temperature tropism,and establish an objective method to estimate the difference of two natural attribute by using a cold/hot plate differentiating technology.The results indicated that the COLD nature Zuojinwan could decrease significantly the remaining rate of HOT-symptom rat on warm pad（P 0.05）.That was not notable to COLD-symptom rat.The interference result of COLD-HOT temperature tropism to COLD/HOT symptom rat in Fanzuojinwan was the reverse with the COLD nature Zuojinwan.Meanwhile,biochemical indicators which are relative to energy metabolism such as ATPase enzyme activity and total anti-oxidant capability（T-AOC）,had corresponding change in the organism.In the study,the COLD and HOT natural tendency in Zuojinwan and Fanzuojinwan which were composed by the same herbs with different proportion could be expressed qualitatively,quantitatively,objectively and directly with applying animal temperature tropism,and be verified to philosophical idea of treating disease theory with ＂expelling heat with cold herbs and cryopathy requiring warm prescription＂,not ＂expelling heat with heat herbs and cryopathy requiring cold prescription＂ in ancient traditional Chinese medicine,which brings a new approach in investigation of the nature theory of traditional Chinese medicine.

关 键 词：寒热属性 动物行为学 温度趋向性 药对 左金丸和反左金丸 

分 类 号：R285[医药卫生—中药学]