小分子化合物ZL-004升高白细胞的作用  

Effect of ZL-004 on raising leukocyte count

作　　者：孙海燕[1] 李春刚[1] 肖璘[1] 王国平[1] 刘全海[1] 

机构地区：[1]上海医药工业研究院,上海200437

出　　处：《药学学报》2010年第6期797-800,共4页Acta Pharmaceutica Sinica

摘　　要：化疗、放疗、手术治疗单独或联合是目前治疗恶性肿瘤的主要手段。放疗、化疗引起的骨髓抑制,造成外周血白细胞减少,是常见和较严重的合并症[1]。临床上除了一般的支持治疗,控制感染,必要时输注粒细胞外,最主要的是应用重组人粒细胞集落刺激因子（rhG-CSF,如赛格力）和重组人粒细胞-巨噬细胞集落刺激因子（rhGM-CSF,如特尔立）,缩短白细胞低下维持的时间,促使白细胞尽快恢复,使化疗或放疗顺利按计划进行[2,3]。This study is to investigate the effect of ZL-004 on normal mouse and mice with leukopenia induced by chemotherapeutic agents.5-Fluorouracil were administered intraperitoneally to mice to develop leucopenia,and the mice were treated with ZL-004.The number of peripheral leukocytes and the percentage of granulocyte in total WBC were examined.The results are that ZL-004 markedly raise peripheral blood leukocytes in the normal mice and the mice model of leukopenia.So,ZL-004 could protect mice against 5-fluorouracil damage and raise peripheral blood leukocyte.Features of bone marrow smears is myeloproliferative hyperactivity in the mice,particularly the matured granulocytic series were observed.The mechanism of ZL-004 is to act on the mouse bone marrow causing proliferation and differentiation.

关 键 词：小分子化合物ZL-004 白细胞减少 升高白细胞 

分 类 号：R965[医药卫生—药理学]