线粒体神经酰胺对细胞凋亡的诱导作用  

Role of Mitochondrial Ceramide in the Induction Apoptosis

作　　者：党旖旎[1] 林苑[1] 朱学江[1] 

机构地区：[1]南京医科大学基础医学实验教学中心,南京市210029

出　　处：《医学分子生物学杂志》2010年第3期251-253,共3页Journal of Medical Molecular Biology

基　　金：国家自然科学基金（No.30871200）

摘　　要：凋亡诱导期,线粒体内神经酰胺水平升高,当每纳摩尔线粒体膜磷脂内含4～6皮摩尔神经酰胺时,神经酰胺即在线粒体外膜形成稳定的跨膜通道,从而使外膜通透性增加,线粒体膜间蛋白释放,启动细胞凋亡.神经酰胺通道只能在线粒体外膜形成,它是由神经酰胺柱组成的桶装结构,神经酰胺的反式双键具有增加通道的稳定性的作用.During the induction phase of apoptosis, mitochondrial ceramide levels elevate to 4 -6 pmot ceramide per nanomole mitochondrial phospholipids and form ceramide channels. Ceramide channel is formed in the mitochondriat buter membrane and stabilized by trans double bond. It is a barrel-like structure, whose staves are ceramide columns that span the membrane. The formation of ceramide channels results in increased permeability of mitochondrial outer membrane and release of intermembrane space proteins that are responsible for a series of actions leading to apoptosis.

关 键 词：伸经酰胺 通道结构 鞘氨醇 细胞凋亡 

分 类 号：R284.1[医药卫生—中药学]