胰岛素样生长因子-1与糖尿病神经病变的关系  

The change of insulin like growth factor 1 in the patients with diabetic neuropathy.

作　　者：郭淮莲[1] 杨毅[1] 耿稚萍[1] 朱良湘[1] 袁申元[1] 赵毅[1] 高玉红[1] 付汉菁[1] 

机构地区：[1]首都医科大学附属北京同仁医院神经内科

出　　处：《中国神经精神疾病杂志》1999年第1期7-9,共3页Chinese Journal of Nervous and Mental Diseases

摘　　要：目的观察胰岛素样生长因子－１（ＩＧＦ－１）与糖尿病神经病变（ＤＮＰ）的关系。方法观察６９例Ⅱ型糖尿病病人，其中ＤＮＰ组５４例，非ＤＮＰ组１５例。正常对照组３４例。观察对象空腹取血检测ＩＧＦ－１、血糖、血红蛋白Ａｌｃ、Ｃ－肽及胰岛素等。血浆ＩＧＦ－１采用放免法检测。结果ＤＮＰ组血浆ＩＧＦ－１水平显著低于非ＤＮＰ组及正常对照组（Ｐ均＜００５）。非ＤＮＰ组与正常对照组间ＩＧＦ－１无显著差异（Ｐ＞００５）。在糖尿病组，ＩＧＦ－１与呼吸差显著正相关，与餐后血糖及天冬氨酸转移酶显著负相关（Ｐ均＜００５）。结论ＤＮＰ患者血浆ＩＧＦ－１显著下降，提示ＩＧＦ－１下降与ＤＮＰ的发生有关。Objective To evaluate the possible relationship between insulin like growth factor 1 (IGF 1) and diabetic neuropathy in diabetic patients.Methods Sixty nine patients with type 2 diabetes (54 with neuropathy and 15 without neuropathy) were observed. Thirty four non diabetic persons were served as controls. After an overnight fast, blood sampls were taken for IGF 1, glucose, hemoglobin Alc, C peptide and insulin detection. Plasma IGF 1 was measured by radioimmunoassay (RIA) method. Results The neuropathy group had significantly lower levels of IGF 1(86.43±45.18 μg/L) compared to controls (119.68±89.42 μg/L) ( P <0.05) and to diabetic patients without neuropathy (113.75±66.58 μg/L) ( P <0.05). No significant difference was found between diabetic non neuropathic group and control subjects ( P >0.05). In diabetic subjects there was a positive correlaion between IGF 1 and beat to beat variation in heart rate ( r=0.27,P<0.05 ) and a negative correlation between IGF 1 and postprandial blood glucose ( r=0.3,P <0.05) or aspartic acid translocase ( r=-0.27,P <0.05). Conclusions Decreased IGF 1 in diabetic patients with peripheral neuropathy may contribute to the pathogensis of neuropathy.

关 键 词：糖尿病 神经病变 DNP IGF-1 神经营养因子 

分 类 号：R587.1[医药卫生—内分泌] R741.02[医药卫生—内科学]