肾绞痛患者血和尿前列腺素水平的测定及其意义  

Clinical significance of serum and urine PGI 2 and TXA 2 in patients with renal colic

作　　者：叶烈夫[1] 宋建达[1] 吴登龙[1] 王继功[1] 邓守贞[1] 

机构地区：[1]上海医科大学华山医院泌尿外科

出　　处：《中华泌尿外科杂志》1999年第1期17-19,共3页Chinese Journal of Urology

摘　　要：目的研究肾绞痛与前列腺素的关系。方法６３例急性肾绞痛患者随机分为两组，实验组服用扶他林２５ｍｇ、ｔｉｄ，共１０天，对照组服用安慰剂，绞痛发作时及１０天后测定患者血和尿中两种前列腺素ＰＧＩ２和ＴＸＡ２水平。结果肾绞痛发作时尿液中这两种前列腺素水平明显增高，实验组服药１０天后血及尿ＰＧＩ２、ＴＸＡ２水平明显降低，且尿中前列腺素水平低于对照组，差异有显著性，证实了前列腺素在肾绞痛发作中的作用。结论服用扶他林能够减少肾绞痛复发次数及止痛剂用量，降低疼痛评分。Objective To study the relationship between the renal colic and the prostaglandlins. Methods Sixty three patients with upper urinary stones went to the emergency room for acute renal colic.They were randomized into two groups: the study group received 25mg voltaren three times daily while the control group multiple vitamin tablets.serum and urine level of PGI 2 and TXA 2 were measured in every patient at an acute attack of colic and ten days later. Results Urine PGI 2 and TXA 2 elevated when suff ering a renal colic.Additionally,the use of voltaren was effective in the prophylactic treatment of renal colic,the pain score,recurrent attacks of severe colic and analgesic reguirement being reduced in the study group. The serum and urine level of PGI 2 and TXA 2 were lower in the study group ten days later, the difference was significant. Conclusions Renal colic results from prostaglandins released by the kidney during acute upper urinary obstruction.Voltaren may prevent recurrent colic through inhibitating prostaglandins synthesized in the kidney.

关 键 词：肾绞痛 前列腺素 测定 药物疗法 扶他林 

分 类 号：R692.05[医药卫生—泌尿科学]