Asymmetric intramolecular oxa-Michael addition of activated α,β-unsaturated ketones by chiral N-triflyl phosphoramide  

作　　者：FENG Zhen ZENG Mi XU QingLong YOU ShuLi 

机构地区：[1]State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

出　　处：《Chinese Science Bulletin》2010年第17期1723-1725,共3页

基　　金：supported by the National Natural Science Foundation of China (20732006 and 20821002)

摘　　要：Asymmetric intramolecular oxa-Michael addition of activated α,β-unsaturated ketones by chiral N-triflyl phosphoramide was realized. The flavanone products can be synthesized with excellent yields (50%–95%) and up to 74% ee.Asymmetric intramolecular oxa-Michael addition of activated α,β-unsaturated ketones by chiral N-triflyl phosphoramide was realized. The flavanone products can be synthesized with excellent yields （50%-95%） and up to 74% ee.

关 键 词：迈克尔 分子氧 不对称 不饱和 黄酮 活性 手性 膦 

分 类 号：O621.2[理学—有机化学]