Asymmetric synthesis of α-aminophosphonates by means of direct organocatalytic three-component hydrophosphonylation  

作　　者：WANG Lian CUI ShuMin MENG Wei ZHANG GuangWu NIE Jing MA JunAn 

机构地区：[1]Department of Chemistry, Tianjin University, Tianjin 300072, China [2]Department of Chemistry, Henan Agricultural University, Zhengzhou 450002, China

出　　处：《Chinese Science Bulletin》2010年第17期1729-1731,共3页

基　　金：supported by the National Natural Science Foundation of China (20772091);Tianjin Municipal Science and Technology Commis-sion (07JCZDJC04700)

摘　　要：The direct asymmetric three-component reaction of an aromatic (or cinnamic) aldehyde, an amine and a phosphite was investigated by employing chiral BrΦnsted acid. In general, modest to good enantioselectivities (31%–87% ee) could be obtained in acceptable isolated yields (61%–91%) for a series of substrates.The direct asymmetric three-component reaction of an aromatic （or cinnamic） aldehyde, an amine and a phosphite was investigated by employing chiral BrФnsted acid. In general, modest to good enantioselectivities （31%-87% ee） could be obtained in acceptable isolated yields （61%-91%） for a series of substrates.

关 键 词：不对称合成 Α-氨基膦酸酯 三组分 有机催化 对映选择性 亚磷酸酯 手性 醛 

分 类 号：O621.251[理学—有机化学]