Chiral pyrrolidine-azole conjugates: Simple and efficient asymmetric organocatalysts for Michael addition to nitrostyrenes  

作　　者：ZHANG Long XU Hui MI XueLing LUO SanZhong CHENG Jin-Pei 

机构地区：[1]Department of Chentistry and State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China [2]Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China

出　　处：《Chinese Science Bulletin》2010年第17期1735-1741,共7页

基　　金：supported by the National Natural Science Foundation of China (20421202, 20632060 and 20702052);the Ministry of Science and Technology of China (2008CB617501 and 2009ZX09501-018) and the Chinese Academy of Sciences.

摘　　要：Simple pyrrolidine-azole conjugates have been synthesized and found to be efficient catalysts for asymmetric Michael addition to nitrostyrenes. The identified optimal catalysts, pyrrolidine-azoles 2, 8 and 13, could catalyze the asymmetric Michael addition of a range of Michael donors and nitrostyrenes in high yields (up to 99%) and excellent stereoselectivities (up to 99:1 dr and 97% ee).Simple pyrrolidine-azole conjugates have been synthesized and found to be efficient catalysts for asymmetric Michael addition to nitrostyrenes. The identified optimal catalysts, pyrrolidine-azoles 2, 8 and 13, could catalyze the asymmetric Michael addition of a range of Michael donors and nitrostyrenes in high yields （up to 99%） and excellent stereoselectivities （up to 99：1 dr and 97% ee）.

关 键 词：不对称MICHAEL加成 有机催化剂 吡咯烷 迈克尔 复合物 三氮唑 手性 高效催化剂 

分 类 号：O621.25[理学—有机化学]