Enantioselective benzoin condensation catalyzed by bifunctional N-heterocyclic carbenes  

作　　者：HUANG XueLiang YE Song 

机构地区：[1]Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China

出　　处：《Chinese Science Bulletin》2010年第17期1753-1757,共5页

基　　金：supported by the National Natural Science Foundation of China (20602036);the Ministry of Science and Technology of China (2009ZX09501-018) and the Chinese Academy of Sciences.

摘　　要：Benzoin condensation is an important carbon-carbon bond-forming reaction. The benzoin reaction with good yield, high enantioselectivity and broad substrate scope is highly desired in organic synthesis. The intermolecular benzoin condensation catalyzed by bifunctional N-heterocyclic carbenes has been investigated, and the corresponding α-hydroxyketones were obtained with yields up to 76% and enantioselectivities up to 99% ee.Benzoin condensation is an important carbon-carbon bond-forming reaction. The benzoin reaction with good yield, high enantioselectivity and broad substrate scope is highly desired in organic synthesis. The intermolecular benzoin condensation catalyzed by bifunctional N-heterocyclic carbenes has been investigated, and the corresponding α-hydroxyketones were obtained with yields up to 76% and enantioselectivities up to 99% ee.

关 键 词：对映选择性 杂环卡宾 安息香 双功能 缩合 催化 有机合成 高选择性 

分 类 号：O643.3[理学—物理化学]