中耳炎病理过程中渗出液的病理转归与肉芽组织的形成  

Transformation of effusion and formation of granulation tissue in the pathologic process of otitis media with effusion

作　　者：张全安[1] 梁建民[1] 

机构地区：[1]西安医科大学第二临床医学院耳鼻咽喉科,西安710004

出　　处：《临床耳鼻咽喉科杂志》1999年第1期8-11,共4页Journal of Clinical Otorhinolaryngology

摘　　要：为探讨中耳炎病理过程中潴留渗出液的病理转归和肉芽组织的形成机理。方法：对美国明尼苏达大学颞骨病理实验室３０６耳各型伴渗出液的中耳炎颞骨连续切片进行了光镜组织病理学观察研究。结果：在中耳炎从早期病理阶段向更晚期病理阶段进展的过程中，渗出液的性质和潴困状态处于动态变化当中；肉芽组织由两种方式的粘膜下成纤维细胞增生而成；潴留渗出液的吸收、机化与肉芽组织形成是同时发生在同一区域的同一病理过程中。结论；肉芽组织仅在渗出液积存和吸收的地方形成；炎性渗出液在中耳停留时间越长，形成肉芽组织的机会就越多，为防止早期伴渗出液的中耳炎向慢性阶段发展，在肉芽组织形成之前彻底引流中耳各处的积液至关重要。To explore the transformation of stagnant effusion(SE) and the pathologic behaviorleading to granulation tissue (GT) formation in the pathologic process of otitis media with effusion (OME).Method: The temporoal bone slides from 306 ears with OME at the Otopathology Laboratory of the University ofMinnesota USA were studied histopathologically under light microscopy. Result: The observations revealed apathologic process in which the type and the condition of stagnant effusion in the coddle ear cleft was variable inthe dynamics of OME progression from an early pathologic stage to an advanced pathologic stage. The granulation tissue was primarily formed by two types of fibroblast proliferation in subepithelial space. The absorptionand the orgnization of SE and the formation of granulation tissue maybe occurs simultaneously in same areas anda same pathologic process. Conclusion :The granulation tissue can only form in the areas where effusion has stagnated and has been absorpted. It is very important that effusion of the otitis media should be removed completlybefore the formation of granulation tissue.

关 键 词：中耳炎 渗出液 病理学 肉芽组织 

分 类 号：R764.210.2[医药卫生—耳鼻咽喉科]