上海嘉定地区连续3年儿童人博卡病毒感染的研究  

Boca virus infection in children in Jiading region of Shanghai

作　　者：严华杰 盛军 董蔚 管丽华 王蔚[2] 王凯[2] 任培君[2] 邵洁[3] 

机构地区：[1]上海市嘉定区南翔医院,上海201802 [2]中国科学院上海巴斯德研究所,上海200025 [3]上海交通大学医学院附属瑞金医院,上海200025

出　　处：《临床儿科杂志》2010年第6期549-551,共3页Journal of Clinical Pediatrics

基　　金：上海市卫生局青年科研项目(No.2007Y77)

摘　　要：目的了解上海市嘉定地区2006—2008年儿童下呼吸道感染患者人博卡病毒感染情况。方法 2006年2月—2008年9月期间,共收集843例下呼吸道感染儿童鼻、咽拭子标本,检测人博卡病毒阳性者进一步检测血液标本。并对其中12例博卡病毒阳性病例回访,再次检测鼻、咽拭子,同时留取血、尿标本。鼻、咽拭子和血、尿液标本均采用RT-PCR方法检测人博卡病毒基因片段。结果 843例鼻、咽拭子标本中博卡病毒阳性90例,阳性率10.7%;其中90例人博卡病毒阳性标本中血标本阳性21例。90例阳性标本中博卡病毒检测阳性率<1岁16.2%,～3岁10.3%,～6岁8.9%。博卡病毒检测阳性率冬季(1～3月)为13.1%,春季(4～6月)为9.9%,夏季(7～9月)为4.1%,秋季(10～12月)为15.3%。确诊博卡病毒感染后14 d,12例患儿再次取鼻、咽拭子以及血、尿液标本,检测出人博卡病毒。结论上海市嘉定地区部分儿童患者的下呼吸道感染与人博卡病毒有关;秋冬季节是人博卡病毒的好发季节;人博卡病毒在感染呼吸道后持续排毒,存在病毒血症可能。Objective To investigate the distribution of human Boca virus infection in children with lower respi-ratory tract infection during three consecutive years（from 2006 to 2008） in Jiading region of Shanghai.Methods Nose and throat swab specimens were collected from 843 children with lower respiratory tract infection between February 2006 and September 2008.Blood specimens were further examined for the patients with positive results in nose and throat swab detection.Human Boca virus DNA fragments were detected by RT-PCR.Twelve patients with positive blood test were followed up,and the specimens of nose and throat swab,blood,and urine were collected and tested again during follow-up time.Results Ninty of 843 patients（10.7%） were Boca virus positive in nose and throat swab specimens.Tweenty-one of the 90 patients were also positive in blood specimens.16.2% of the 90 patients were infants under one-year-old,10.3% were between 1 to 3 years,and 8.9% were between three to six years.Boca virus-positive rate was 13.1% in winter（from January to March）,10% in spring（from April to June）,4% in summer（from July to September）,and 15% in autumn（from October to December）.The nose and throat swabs,and blood specimens were still positive for Boca virus in the 12 patients within the 14 days follow-up time.Conclusions Lower respiratory tract infection in children in Jiading region of Shanghai was associated with human Boca virus,and the infection was more common in autumn and winter.The virus will be released continuously after respiratory tract infection,and viremia was present.

关 键 词：人博卡病毒 下呼吸道感染 儿童 

分 类 号：R725.1[医药卫生—儿科]