白藜芦醇苷对PC12细胞氧糖剥夺损伤模型的保护作用  

Protective effect of polydatin on a PC12 cell model of oxygen-glucose deprivation

作　　者：徐冰[1] 林焕冰[1] 周恒[1] 徐江平[1] 

机构地区：[1]南方医科大学药学院药理学系,广东广州510515

出　　处：《南方医科大学学报》2010年第5期1041-1043,共3页Journal of Southern Medical University

基　　金：广东省自然科学基金重点项目(7117782);广东省科技计划项目中医药现代化重点专项(粤财教[2008]258号)

摘　　要：目的探讨白藜芦醇苷对PC12细胞缺氧缺糖损伤模型的保护作用。方法以缺氧缺糖诱导PC12细胞损伤模型模拟脑缺血病理的改变,研究白藜芦醇苷对该缺氧缺糖损伤模型的影响。结果白藜芦醇苷能显著减少PC12细胞死亡,降低乳酸脱氢酶漏出量,一氧化氮含量及丙二醛生成,提高超氧化物歧化酶活性。结论白藜芦醇苷对PC12细胞缺氧缺糖损伤具有保护作用。Objective To evaluate the protective effect of polydatin on a PC12 cell model of oxygen and glucose deprivation （OGD）. Methods A pheochromocytoma cell injury model was induced by OGD to simulate the cerebral ischemic changes. The protective effects of polydatin were investigated in this model. Results Polydatin treatment significantly enhanced the cell viability and reduced the levels of lactate dehydrogenase, nitric oxide and the malondialdehyde of the pheochromocytoma cells as compared with the OGD group. Polydatin also increased the activity of superoxide dismutase in the cells. Conclusion Polydatin offers protective effect against OGD-induced injury in pheochromocytoma cells.

关 键 词：白藜芦醇苷 PC12细胞 氧糖剥夺损伤模型 

分 类 号：R285.5[医药卫生—中药学]