光学相干断层成像评价国产新型药物洗脱支架术后内膜增殖  

Optical coherence tomography for evaluation of neointimal proliferation after placement of a new drug eluting stent

作　　者：刘长福[1] 陈韵岱[1] 陈练[1] 孙志军[1] 盖鲁粤[1] 刘宏斌[1] 任艺虹[1] 田峰[1] 白启才[1] 郭凯[1] 

机构地区：[1]中国人民解放军总医院心血管内科,北京100853

出　　处：《南方医科大学学报》2010年第5期1063-1065,共3页Journal of Southern Medical University

摘　　要：目的应用光学相干断层成像技术评价新型国产冠状动脉雷帕霉素药物洗脱支架(BUMA)置入后内膜覆盖。方法入选22例冠状动脉造影提示为原发冠状动脉病变需置入支架的冠心病患者,随机分为BUMA组(n=15)和对照组Endeavor组(n=7),术后9个月行光学相干断层成像检查。结果 BUMA组平均内膜增殖厚度显著小于Endeavor组(0.220±0.140mm对0.269±0.207mm,P<0.001);BUMA组无内膜覆盖百分率显著低于Endeavor组(5.65%对6.56%,P<0.001);BUMA组支架内管腔面积丢失显著小于Endeavor组有统计学差异[(34.87±11.50)%对(40.82±18.53)%,P=0.025]。结论冠心病患者置入国产新型BUMA药物洗脱支架具有良好的安全性和有效性。Objective To evaluate neointimal proliferation following placement of a new drug-eluting stent （BUMA） by optical coherence tomography （OCT）. Methods Twenty-two patients with coronary artery disease were randomized into BUMA group （n=15） and Endeavor group （n=7） and underwent OCT imaging after 9 months of stent implantation. Results The neointima hyperplasia （NIH） thickness in BUMA group were significantly smaller than that in endeavor group （0.220± 0.140 mm vs 0.269±0.207mm, P0.001）, and the uncovered Struts were significantly lower in BUMA group than in Endeavor group （5.65% vs 6.56%, P0.0001）. The luminal late loss in BUMA group was also significantly lower （34.87±11.50 vs 40.82±18.53, P=0.025）. Conclusion BUMA stent is safe and effective for treatment of coronary artery disease.

关 键 词：冠状动脉疾病 光学相干断层成像 药物洗脱支架 内膜增殖 

分 类 号：R541.4[医药卫生—心血管疾病]